Solitary fibrous tumour of the oral cavity: clinicopathological and immunohistochemical characterization of three cases

: Solitary fibrous tumour (SFT) is an uncommon mesenchymal neoplasm rarely located in the oral cavity. To characterize further oral SFT, we describe three new cases. Each tumour originated in the buccal mucosa of a middle‐aged/elderly patient. Histological examination showed well‐circumscribed tumou...

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Bibliographic Details
Published in:Journal of oral pathology & medicine 2000-04, Vol.29 (4), p.186-192
Main Authors: Lukinmaa, Pirjo‐Liisa, Hietanen, Jarkko, Warfvinge, Gunnar, Sane, Juha, Tuominen, Susanne, Henriksson, Vincent, Larsson, Åke
Format: Article
Language:English
Subjects:
Aged
Antigens, CD34 - analysis
bcl‐2
Biological and medical sciences
Blood Vessels - pathology
CD34
Cell Nucleus - ultrastructure
Collagen
Dentistry
Diagnosis, Differential
Female
histology
Humans
Immunohistochemistry
Ki-67 Antigen - analysis
Male
Mast Cells - pathology
Medical sciences
Middle Aged
Mitosis
Mouth Mucosa - pathology
Mouth Neoplasms - pathology
Neoplasms, Fibrous Tissue - pathology
oral cavity
Otorhinolaryngology. Stomatology
Proto-Oncogene Proteins c-bcl-2 - analysis
solitary fibrous tumour (SFT)
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
vimentin
Vimentin - analysis
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Summary:: Solitary fibrous tumour (SFT) is an uncommon mesenchymal neoplasm rarely located in the oral cavity. To characterize further oral SFT, we describe three new cases. Each tumour originated in the buccal mucosa of a middle‐aged/elderly patient. Histological examination showed well‐circumscribed tumours with densely cellular areas alternating with hypocellular areas in a variedly collagenous, vascular stroma. Mast cells were abundant. The spindle‐shaped, neoplastic cells immunostained strongly for CD34 antigen and vimentin and weakly for bcl‐2, but not for epithelial cell markers, α‐smooth muscle actin, or neurofilament or S‐100 proteins. Compatible with the virtual absence of mitoses and of marked nuclear atypia, the overall frequency of proliferating cells expressing Ki‐67 was low. The expression of CD34 was useful in the differential diagnosis. The consistent location in the cheek and expansion of one tumour after local trauma does not preclude a traumatic element in the development of oral SFT.
ISSN:0904-2512
1600-0714
DOI:10.1034/j.1600-0714.2000.290407.x