Does Reversal of Ischemia on Diffusion-Weighted Imaging Reflect Higher Apparent Diffusion Coefficient Values?

ABSTRACT This study investigated whether ischemia on diffusion‐weighted imaging (DWI) that reverses has higher apparent diffusion coefficients (ADCs). A patient treated with thrombolytics was evaluated with serial magnetic resonance imaging studies before treatment, at 3 and 14 days and at 4 weeks....

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Bibliographic Details
Published in:Journal of neuroimaging 2001-07, Vol.11 (3), p.313-316
Main Authors: Lutsep, Helmi L., Nesbit, Gary M., Berger, Richard M., Coshow, William R.
Format: Article
Language:English
Subjects:
apparent diffusion coefficient
Brain Ischemia - diagnosis
Brain Ischemia - drug therapy
cerebral ischemia
diffusion-weighted imaging
Female
fluid attenuated inversion recovery
Humans
Magnetic Resonance Imaging - methods
Middle Aged
Thrombolytic Therapy
thrombolytic treatment
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Summary:ABSTRACT This study investigated whether ischemia on diffusion‐weighted imaging (DWI) that reverses has higher apparent diffusion coefficients (ADCs). A patient treated with thrombolytics was evaluated with serial magnetic resonance imaging studies before treatment, at 3 and 14 days and at 4 weeks. A 100.01‐cm3left frontoparietal stroke on baseline DWI was only 18.11 cm3(18%) on 4‐week fluid attenuated inversion recovery. The mean ADC was 7.43 × 10−3mm2/s in the 6 regions that reversed and 7.31 × 10−3mm2/s in the 6 regions that persisted (P < .036). With thrombolytic treatment, large ischemic lesions on DWI may reverse, and these areas display higher mean ADCs.
ISSN:1051-2284
1552-6569
DOI:10.1111/j.1552-6569.2001.tb00053.x