Central and peripheral dysregulation of melanin-concentrating hormone in obese Zucker rats

Melanin concentrating hormone (MCH) is a peptide synthesized in the lateral hypothalamus which stimulates food ingestion and leptin secretion in rodents. In this experiment, we measured the expressions of MCH as well as of its receptor (SLC-1) in the hypothalamus of obese hyperphagic and lean Zucker...

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Bibliographic Details
Published in:Brain research. Molecular brain research. 2001-08, Vol.92 (1), p.43-48
Main Authors: Stricker-Krongrad, Alain, Dimitrov, Todor, Beck, Bernard
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Carrier Proteins - genetics
Disease Models, Animal
Food intake
Gene Expression Profiling
Genotype
Hypothalamic Area, Lateral - metabolism
Hypothalamic Hormones - metabolism
Leptin - blood
Leptin - metabolism
Male
MCH receptor
Medical sciences
Melanins - metabolism
Metabolic diseases
Neuropeptide
Obesity
Obesity - genetics
Obesity - metabolism
Pituitary Hormones - metabolism
Point Mutation
Prepro-MCH
Protein Precursors - metabolism
Rats
Rats, Zucker
Receptors, Cell Surface
Receptors, Leptin
Receptors, Pituitary Hormone - metabolism
Zucker rat
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Summary:Melanin concentrating hormone (MCH) is a peptide synthesized in the lateral hypothalamus which stimulates food ingestion and leptin secretion in rodents. In this experiment, we measured the expressions of MCH as well as of its receptor (SLC-1) in the hypothalamus of obese hyperphagic and lean Zucker rats by quantitative real time RT-PCR. MCH mRNA expression in the obese rats was significantly increased by a factor of five ( P
ISSN:0169-328X
1872-6941
DOI:10.1016/S0169-328X(01)00130-9