N-Methyl-D-aspartate receptor blockade during development induces short-term but not long-term changes in c-jun and parvalbumin expression in the rat cervical spinal cord

During postnatal development, N-methyl-D-aspartate receptor (NMDA-R) expression progressively decreases in ventral and deep dorsal horns. This transient expression might play a role in activity-dependent development of segmental circuitry. NMDA-Rs were blocked unilaterally in the lower cervical spin...

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Bibliographic Details
Published in:Experimental neurology 2001-08, Vol.170 (2), p.380-384
Main Authors: GIBSON, Claire L, CLOWRY, Gavin J
Format: Article
Language:English
Subjects:
Aging
Animals
Animals, Newborn
Biological and medical sciences
Development. Senescence. Regeneration. Transplantation
Dizocilpine Maleate - administration & dosage
Dizocilpine Maleate - pharmacology
Drug Implants
Functional Laterality
Fundamental and applied biological sciences. Psychology
Genes, jun
Motor Neurons - cytology
Motor Neurons - drug effects
Motor Neurons - physiology
Parvalbumins - analysis
Parvalbumins - metabolism
Polyvinyls
Proto-Oncogene Proteins c-jun - analysis
Proto-Oncogene Proteins c-jun - metabolism
Rats
Rats, Wistar
Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors
Spinal Cord - drug effects
Spinal Cord - growth & development
Spinal Cord - physiology
Vertebrates: nervous system and sense organs
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Summary:During postnatal development, N-methyl-D-aspartate receptor (NMDA-R) expression progressively decreases in ventral and deep dorsal horns. This transient expression might play a role in activity-dependent development of segmental circuitry. NMDA-Rs were blocked unilaterally in the lower cervical spinal cord using Elvax implants that released the NMDA-R antagonist MK-801 maximally over a 2-week period from postnatal day 7 (P7) onward. At P14, the ratio of c-Jun immunoreactive motoneurons ipsilateral/contralateral to the implants was significantly increased and the ratio of parvalbumin immunoreactive neurons decreased, compared to control implants. However, at P84, MK-801-treated and control spinal cords appeared the same. Therefore, NMDA-R blockade during development only transiently altered expression of activity-dependent proteins in the spinal cord, unlike lesions to the developing motor cortex, which we have previously shown to have a permanent effect.
ISSN:0014-4886
1090-2430
DOI:10.1006/exnr.2001.7720