Kaposi's Sarcoma‐Associated Herpesvirus: From Cell Biology to Pathogenesis

Kaposi's sarcoma‐associated herpesvirus (KSHV or HHV‐8) is linked to the etiopathogenesis of Kaposi's sarcoma, a plasmablastic variant of Castleman's disease and primary effusion lymphoma. KSHV is related to a number of non‐human primate viruses. Only a limited number of KSHV proteins...

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Bibliographic Details
Published in:IUBMB life 2000-02, Vol.49 (2), p.97-104
Main Authors: Sharp, Tyson V., Boshoff, Chris
Format: Article
Language:English
Subjects:
AIDS/HIV
Carcinogenesis
Castleman Disease - microbiology
Cell Cycle
Herpesvirus
Herpesvirus 8, Human - classification
Herpesvirus 8, Human - genetics
Herpesvirus 8, Human - pathogenicity
Humans
Kaposis
Lymphoma - microbiology
Sarcoma
Sarcoma, Kaposi - microbiology
Viral
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Summary:Kaposi's sarcoma‐associated herpesvirus (KSHV or HHV‐8) is linked to the etiopathogenesis of Kaposi's sarcoma, a plasmablastic variant of Castleman's disease and primary effusion lymphoma. KSHV is related to a number of non‐human primate viruses. Only a limited number of KSHV proteins are expressed in tumor cells. Here we discuss the putative role of these proteins in KSHV pathogenesis.
ISSN:1521-6543
1521-6551
DOI:10.1080/15216540050022395