Synthesis of Diverse and Complex Molecules on the Solid Phase

In this paper we summarize our efforts toward optimizing key reactions on the solid phase which tolerate a variety of functional groups. These groups were sequentially modified, allowing the production of novel and diverse compound libraries on the solid phase.

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Bibliographic Details
Published in:Accounts of chemical research 2000-04, Vol.33 (4), p.215-224
Main Authors: Wendeborn, Sebastian, De Mesmaeker, Alain, Brill, Wolfgang K.-D, Berteina, Sabine
Format: Article
Language:English
Subjects:
Animals
Chemistry, Organic
Cyclization
Humans
Organic Chemistry Phenomena
Palladium
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Description
Summary:In this paper we summarize our efforts toward optimizing key reactions on the solid phase which tolerate a variety of functional groups. These groups were sequentially modified, allowing the production of novel and diverse compound libraries on the solid phase.
ISSN:0001-4842
1520-4898
DOI:10.1021/ar990100d