Synthesis and antibacterial activity of novel 6-O-substituted erythromycin A derivatives

A series of novel 6-O-substituted erythromycin A derivatives has been synthesized. Good in vitro antibacterial activity has been demonstrated for analogues incorporating a variety of structural features. The methodology disclosed is expected to find application in the design of future macrolide anti...

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Published in:Bioorganic & medicinal chemistry letters 2000-04, Vol.10 (8), p.815-819
Main Authors: CLARK, R. F, ZHENKUN MA, YAT SUN OR, SANYI WANG, GRIESGRABER, G, TUFANO, M, HONG YONG, LEPING LI, XIAOLIN ZHANG, NILIUS, A. M, CHU, D. T. W
Format: Article
Language:English
Subjects:
Anti-Infective Agents - chemical synthesis
Anti-Infective Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Erythromycin - analogs & derivatives
Erythromycin - chemical synthesis
Erythromycin - pharmacology
Medical sciences
Microbial Sensitivity Tests
Pharmacology. Drug treatments
Structure-Activity Relationship
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cited_by cdi_FETCH-LOGICAL-c266t-cfca278f3e1fb68dd7b0c685179481c8734ecb871d57c1e046b2877b362c2bd33
cites cdi_FETCH-LOGICAL-c266t-cfca278f3e1fb68dd7b0c685179481c8734ecb871d57c1e046b2877b362c2bd33
container_end_page 819
container_issue 8
container_start_page 815
container_title Bioorganic & medicinal chemistry letters
container_volume 10
creator CLARK, R. F
ZHENKUN MA
YAT SUN OR
SANYI WANG
GRIESGRABER, G
TUFANO, M
HONG YONG
LEPING LI
XIAOLIN ZHANG
NILIUS, A. M
CHU, D. T. W
description A series of novel 6-O-substituted erythromycin A derivatives has been synthesized. Good in vitro antibacterial activity has been demonstrated for analogues incorporating a variety of structural features. The methodology disclosed is expected to find application in the design of future macrolide antibiotics that target the prevalent bacterial resistance problem.
doi_str_mv 10.1016/S0960-894X(00)00106-2
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ispartof Bioorganic & medicinal chemistry letters, 2000-04, Vol.10 (8), p.815-819
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subjects Anti-Infective Agents - chemical synthesis
Anti-Infective Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Erythromycin - analogs & derivatives
Erythromycin - chemical synthesis
Erythromycin - pharmacology
Medical sciences
Microbial Sensitivity Tests
Pharmacology. Drug treatments
Structure-Activity Relationship
title Synthesis and antibacterial activity of novel 6-O-substituted erythromycin A derivatives
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