Sox8 gene expression identifies immature glial cells in developing cerebellum and cerebellar tumours

Sox8 is a member of the E subgroup of Sox genes, the other members of which are Sox9 and Sox10, both of which are implicated in specific human disorders. Recently, Sox8 homologues have been cloned in chick, mouse and human and have been shown to be strongly expressed in the embryonic and adult brain...

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Bibliographic Details
Published in:Brain research. Molecular brain research. 2001-08, Vol.92 (1), p.193-200
Main Authors: Cheng, Yi-Chuan, Lee, Ching-Jung, Badge, Richard M., Orme, Alex T., Scotting, Paul J.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Biomarkers
Brain Neoplasms - metabolism
Brain Neoplasms - pathology
Cerebellar Neoplasms - metabolism
Cerebellar Neoplasms - pathology
Cerebellum
Cerebellum - cytology
Cerebellum - embryology
Cerebellum - metabolism
Chick Embryo
DNA-Binding Proteins - biosynthesis
DNA-Binding Proteins - genetics
Gene Expression Profiling
Gene Expression Regulation, Developmental
Gene Library
Glial cells
Glioma - metabolism
Glioma - pathology
Humans
In Situ Hybridization
Medical sciences
Medulloblastoma
Medulloblastoma - metabolism
Medulloblastoma - pathology
Neoplasm Proteins - biosynthesis
Neoplasm Proteins - genetics
Nerve Tissue Proteins - biosynthesis
Nerve Tissue Proteins - genetics
Neuroglia - metabolism
Neurology
Sox8
Sox8 gene
SOXE Transcription Factors
Transcription Factors - biosynthesis
Transcription Factors - genetics
Transcription, Genetic
Tumors of the nervous system. Phacomatoses
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Summary:Sox8 is a member of the E subgroup of Sox genes, the other members of which are Sox9 and Sox10, both of which are implicated in specific human disorders. Recently, Sox8 homologues have been cloned in chick, mouse and human and have been shown to be strongly expressed in the embryonic and adult brain. Nevertheless, the cell types that express Sox8 have not been determined. We show here that Sox8 is expressed in immature glia in the developing cerebellum. Sox8 is also expressed in scattered cells in the cerebellar tumour, medulloblastoma. This gene therefore provides an early glial marker that may provide more detailed insight into the cellular makeup and consequent behaviour of medulloblastomas.
ISSN:0169-328X
1872-6941
DOI:10.1016/S0169-328X(01)00147-4