Effect of chronic ethanol ingestion and exercise training on skeletal muscle in rat

The aim of this study was to investigate the interactive effects of exercise training and chronic ethanol consumption on metabolism, capillarity, and myofibrillar composition in rat limb muscles. Male Wistar rats were treated in separate groups as follows: non exercised-control; ethanol (15%) in ani...

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Bibliographic Details
Published in:Drug and alcohol dependence 2001-09, Vol.64 (1), p.27-33
Main Authors: Vila, L., Ferrando, A., Voces, J, Cabral de Oliveira, C., Prieto, J.G., Alvarez, A.I.
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
Biological and medical sciences
Capillaries - drug effects
Capillarity
Ethanol
Ethanol - pharmacology
Exercise
Fiber area
Fiber type
General aspects
Male
Medical sciences
Muscle Fibers, Fast-Twitch - metabolism
Muscle Fibers, Fast-Twitch - ultrastructure
Muscle metabolism
Muscles - blood supply
Muscles - drug effects
Muscles - physiology
Physical Conditioning, Animal
Rats
Rats, Wistar
Spectrophotometry
Time Factors
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Summary:The aim of this study was to investigate the interactive effects of exercise training and chronic ethanol consumption on metabolism, capillarity, and myofibrillar composition in rat limb muscles. Male Wistar rats were treated in separate groups as follows: non exercised-control; ethanol (15%) in animals’ drinking water for 12 weeks; exercise training in treadmill and ethanol administration plus exercise for 12 weeks. Ethanol administration decreased capillarity and increased piruvate kinase and lactate dehydrogenase activities in white gastrocnemius; in plantaris muscle, ethanol increased citrate synthase activity and decreased cross-sectional area of type I, IIa, and IIb fibres. Exercise increased capillarity in all four limb muscles and decreased type I fibre area in plantaris. The decreased capillarity effect induced by ethanol in some muscles, was ameliorated when alcohol was combined with exercise. While alcoholic myopathy affects predominantly type IIb fibres, ethanol administration and aerobic exercise in some cases can affect type I and type IIa fibre areas. The exercise can decrease some harmful effects produced by ethanol in the muscle, including the decrease in the fibre area and capillary density.
ISSN:0376-8716
1879-0046
DOI:10.1016/S0376-8716(00)00223-4