Early migration of cutaneous lymphocyte-associated antigen (CLA) positive T cells into evolving psoriatic plaques

: The majority of T cells in lesional psoriatic skin express the skin homing receptor, cutaneous lymphocyte‐associated antigen (CLA). We investigated whether this reflects the selective migration of CLA positive cells into evolving psoriatic plaques, consistent with an important role in disease onse...

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Bibliographic Details
Published in:Experimental dermatology 2001-08, Vol.10 (4), p.280-285
Main Authors: Davison, S. C., Ballsdon, A., Allen, M. H., Barker, J. N. W. N.
Format: Article
Language:English
Subjects:
Adult
Antigens, Differentiation, T-Lymphocyte
Antigens, Neoplasm
Biological and medical sciences
Cell Movement
Dermatology
Doppler fluxmetry
Epidermis - metabolism
Epidermis - pathology
Female
Humans
Immunohistochemistry
Ki-67 Antigen - analysis
Male
Medical sciences
Membrane Glycoproteins - analysis
Middle Aged
psoriasis
Psoriasis - immunology
Psoriasis - pathology
Psoriasis - physiopathology
Psoriasis. Parapsoriasis. Lichen
Skin - metabolism
Skin - pathology
skin-homing lymphocyte
T-Lymphocytes - immunology
T-Lymphocytes - pathology
T-Lymphocytes - physiology
Time Factors
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Summary:: The majority of T cells in lesional psoriatic skin express the skin homing receptor, cutaneous lymphocyte‐associated antigen (CLA). We investigated whether this reflects the selective migration of CLA positive cells into evolving psoriatic plaques, consistent with an important role in disease onset, or whether this occurs in the context of an established cutaneous inflammatory response. We identified the advancing edge of plaques in 16 patients with chronic plaque psoriasis using scanning laser Doppler fluxmetry, and performed immunohistochemical analysis of i) lesional psoriatic skin, ii) clinically normal skin immediately in front of the advancing plaque edge, and iii) uninvolved skin distant from the plaque edge. The T‐cell infiltrate was characterized using monoclonal antibodies to CD3, CLA and the integrin αEβ7, which is associated with the retention of lymphocytes at mucosal sites. Epithelial proliferation was assessed using a monoclonal antibody to the nuclear proliferation marker Ki67. There was enrichment of CLA positive T cells in evolving psoriatic skin compared to distant, uninvolved skin (mean CLA positive 75.9% vs 47.8%; P
ISSN:0906-6705
1600-0625
DOI:10.1034/j.1600-0625.2001.100408.x