Preferential cytotoxicity of caffeic acid phenethyl ester analogues on oral cancer cells

As part of our previous search for new compounds with improved biological activities including antibiotic, antiviral, anti-inflammatory, and tumor growth inhibition activities, we synthesized some caffeic acid phenethyl ester (CAPE)-like compounds from commercially available caffeic acid. Nine chemi...

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Bibliographic Details
Published in:Cancer letters 2000-05, Vol.153 (1), p.51-56
Main Authors: Lee, Yean-Jang, Liao, Pel-Hu, Chen, Wen-Kang, Yang, Chi-Chiang
Format: Article
Language:English
Subjects:
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Biological and medical sciences
Caffeic acid phenethyl ester
Caffeic Acids - chemical synthesis
Caffeic Acids - chemistry
Caffeic Acids - pharmacology
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Gingiva carcinoma
Humans
Medical sciences
Mouth Neoplasms - pathology
Otorhinolaryngology. Stomatology
Phenylethyl Alcohol - analogs & derivatives
Phenylethyl Alcohol - chemical synthesis
Phenylethyl Alcohol - chemistry
Phenylethyl Alcohol - pharmacology
Tongue squamous cell carcinoma
Tumor Cells, Cultured
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Summary:As part of our previous search for new compounds with improved biological activities including antibiotic, antiviral, anti-inflammatory, and tumor growth inhibition activities, we synthesized some caffeic acid phenethyl ester (CAPE)-like compounds from commercially available caffeic acid. Nine chemicals were tested by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay on the growth of buccal mucosal fibroblast (BF), oral submucosus fibroblast (OSF), neck metastasis of Gingiva carcinoma (GNM), and tongue squamous cell carcinoma (TSCCa) cells. CAPE and its ethyl analogue show significant cytotoxicity on OSF, GNM, and TSCCa cells, but not on BF cells. The results suggest that CAPE-like compounds may be potential chemotherapy agents against oral cancer.
ISSN:0304-3835
1872-7980
DOI:10.1016/S0304-3835(00)00389-X