Proton magnetic resonance spectroscopy (1H-MRS) of motor cortex and basal ganglia in de novo Parkinson's disease patients

Proton MR spectroscopy (1H-MRS) has been previously performed in Parkinson's disease (PD) and parkinsonian syndromes to evaluate in vivo concentrations of basal ganglia and cerebral cortex metabolites such as N-acetylaspartate (NAA), choline (Cho), and creatine (Cr). However, this technique has...

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Bibliographic Details
Published in:Neurological sciences 2001-02, Vol.22 (1), p.69-70
Main Authors: Lucetti, C, Del Dotto, P, Gambaccini, G, Bernardini, S, Bianchi, M C, Tosetti, M, Bonuccelli, U
Format: Article
Language:English
Subjects:
Aged
Aspartic Acid - analogs & derivatives
Aspartic Acid - metabolism
Basal Ganglia - metabolism
Basal Ganglia - physiopathology
Brain
Brain Chemistry - physiology
Choline - metabolism
Creatine - metabolism
Female
Humans
Inositol - metabolism
Magnetic Resonance Spectroscopy
Male
Middle Aged
Motor Cortex - metabolism
Motor Cortex - physiopathology
Neurosciences
Parkinson Disease - diagnosis
Parkinson Disease - metabolism
Parkinson Disease - physiopathology
Spectrum analysis
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Summary:Proton MR spectroscopy (1H-MRS) has been previously performed in Parkinson's disease (PD) and parkinsonian syndromes to evaluate in vivo concentrations of basal ganglia and cerebral cortex metabolites such as N-acetylaspartate (NAA), choline (Cho), and creatine (Cr). However, this technique has never been used to evaluate motor cortex in untreated PD patients. In this study, single-voxel 1H-MRS of basal ganglia and motor cortex was carried out in 10 de novo patients with PD and 10 age-matched healthy controls. A significant reduction in the NAA/Cr ratio was observed in the motor cortex of PD patients compared with controls (p)
ISSN:1590-1874
1590-3478
DOI:10.1007/s100720170051