Fungicidal activity of natural and synthetic sesquiterpene lactone analogs

Fungicidal activity of 36 natural and synthetic sesquiterpene lactones with guaianolide, trans, trans-germacranolide, cis, cis-germacranolide, melampolide, and eudesmanolide carbon skeletons was evaluated against the phytopathogenic fungi Colletotrichum acutatum, C. fragariae, C. gloeosporioides, Fu...

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Bibliographic Details
Published in:Phytochemistry (Oxford) 2000-04, Vol.53 (7), p.747-757
Main Authors: Wedge, D.E., Galindo, J.C.G., Macı́as, F.A.
Format: Article
Language:English
Subjects:
5α-Hydroxydehydrocostuslactone
Antifungal Agents - chemistry
Antifungal Agents - pharmacology
Biological and medical sciences
Botrytis cinerea
Chemical control
Colletotrichum acutatum
Colletotrichum fragariae
Colletotrichum gloeosporioides
Control
Costunolide
Dehydrocostuslactone
Dehydrozaluzanin C
Fundamental and applied biological sciences. Psychology
Fungal plant pathogens
Fungicides
Fusarium oxysporum
Magnetic Resonance Spectroscopy
Mass Spectrometry
Microbial Sensitivity Tests
microtiter assay
Phomopsis
Phomopsis sp
Phytopathology. Animal pests. Plant and forest protection
Sesquiterpene lactones
Sesquiterpenes - chemistry
Sesquiterpenes - pharmacology
Zaluzanin C
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Summary:Fungicidal activity of 36 natural and synthetic sesquiterpene lactones with guaianolide, trans, trans-germacranolide, cis, cis-germacranolide, melampolide, and eudesmanolide carbon skeletons was evaluated against the phytopathogenic fungi Colletotrichum acutatum, C. fragariae, C. gloeosporioides, Fusarium oxysporum, Botrytis cinerea, and Phomopsis sp. Dose-response data for the active compounds dehydrozaluzanin C, dehydrocostuslactone, 5α-hydroxydehydrocostuslacone, costunolide, and zaluzanin C are presented. A new 96-well microbioassay procedure for fast and easy evaluation of antifungal activity was used to compare these compounds with commercial fungicide standards. Some structure-activity conclusions are also presented.
ISSN:0031-9422
1873-3700
DOI:10.1016/S0031-9422(00)00008-X