Polyamine oxidase activity in sera of depressed and schizophrenic patients after ECT treatment

High level of polyamine oxidase activity is detected in sera of depressed as well as in schizophrenic patients. ECT treatment of depressed and schizophrenic patients reduced significantly the level of polyamine oxidase activity in their sera. After ECT treatment, clinically improved depressed and sc...

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Bibliographic Details
Published in:Neurochemical research 2001-04, Vol.26 (4), p.415-418
Main Authors: DAHEL, Khair Al-Deen, AL-SAFFAR, Najat M, FLAYEH, Khawola A
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Biological and medical sciences
Depression - blood
Depression - enzymology
Depression - therapy
Electroconvulsive Therapy
Humans
Medical sciences
Oxidoreductases Acting on CH-NH Group Donors - blood
Polyamine Oxidase
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Schizophrenia
Schizophrenia - blood
Schizophrenia - enzymology
Schizophrenia - therapy
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Summary:High level of polyamine oxidase activity is detected in sera of depressed as well as in schizophrenic patients. ECT treatment of depressed and schizophrenic patients reduced significantly the level of polyamine oxidase activity in their sera. After ECT treatment, clinically improved depressed and schizophrenic subjects were found to have sera polyamine oxidase activity not significantly differ from that of normal subjects. Possible biochemical mechanisms, which link polyamine oxidase activity, schizophrenia, depression and ECT effect are discussed here.
ISSN:0364-3190
1573-6903
DOI:10.1023/A:1010959300545