Some specific human leukocyte antigen (HLA)-DR/DQ haplotypes are more important than individual HLA-DR and -DQ phenotypes for the development of mucocutaneous type of Behçet's disease and for disease shift from recurrent aphthous stomatitis to mucocutaneous type of Behçet's disease

• Published in: Journal of oral pathology & medicine 2001-08, Vol.30 (7), p.402-407
• Main Authors: Sun, Andy, Hsieh, Rhong-Phong, Chu, Chien-Ts, Wang, Jeng-Tzung, Liu, Bu-Yuan, Chiang, Chun-Pin
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Algorithms; Behcet Syndrome - genetics; Behçet's disease; Biological and medical sciences; Chi-Square Distribution; Child; China; Chinese; Dentistry; Female; Haplotypes - genetics; HLA-DQ Antigens - genetics; HLA-DR Antigens - genetics; HLA-DR Serological Subtypes; HLA-DR/DQ haplotypes; Humans; Male; Medical sciences; Middle Aged; Non tumoral diseases; Odds Ratio; Otorhinolaryngology. Stomatology; Phenotype; Recurrence; Risk Factors; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Statistics as Topic; Stomatitis, Aphthous - genetics; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
• ISSN: 0904-2512; 1600-0714
• DOI: 10.1034/j.1600-0714.2001.300704.x

: The phenotype and haplotype frequencies of human leukocyte antigens (HLA)‐DR and ‐DQ in 32 Chinese patients with the mucocutaneous (MC) type of Behçet’s disease (BD) were calculated and compared with those in 310 healthy control Chinese and with those in 80 Chinese patients with recurrent aphthous stomatitis (RAS). We found that the phenotype frequency of HLA‐DRw8 [corrected P (Pc)