Factors regulating renal angiotensin-converting enzyme activity in the rat

Changes in angiotensin‐converting enzyme (ACE) activity appear to be important in mediating the natriuresis which ensues after administration of an oral or gastric sodium load. In this study, we sought to determine the time course of the changes in ACE activity in the kidney which occur after sodium...

Full description

Saved in:
Bibliographic Details
Published in:Acta physiologica Scandinavica 2000-05, Vol.169 (1), p.21-27
Main Authors: YE, V. Z. C, DUGGAN, K. A
Format: Article
Language:English
Subjects:
angiotensin-converting enzyme
Animals
Biological and medical sciences
Denervation
Fundamental and applied biological sciences. Psychology
gastric sodium monitor
Injections, Intravenous
Intestinal Absorption - physiology
Kidney - enzymology
Kidney - innervation
Male
Natriuresis - physiology
Osmolar Concentration
Peptidyl-Dipeptidase A - metabolism
Peripheral Nerves - physiology
Rats
Rats, Sprague-Dawley
renal ACE activity
sodium loading
Sodium, Dietary - blood
Sodium, Dietary - pharmacokinetics
Stomach - metabolism
Urea - pharmacology
Vertebrates: urinary system
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Changes in angiotensin‐converting enzyme (ACE) activity appear to be important in mediating the natriuresis which ensues after administration of an oral or gastric sodium load. In this study, we sought to determine the time course of the changes in ACE activity in the kidney which occur after sodium ingestion. In addition, we sought to investigate mechanisms which might underlie these changes. Angiotensin‐converting enzyme activity was measured by generation of histidyl‐leucine in homogenates of kidneys harvested at varying time‐points after gastric sodium administration. The effects of intravenous sodium loading, solution osmolality and of changes in renal nerve activity were also investigated. Intragastric instillation of both the sodium‐containing solution and its iso‐osmotic urea control solution resulted in significant increases in renal ACE activity (NaCl: P 
ISSN:0001-6772
1365-201X
DOI:10.1046/j.1365-201x.2000.00720.x