Neuroimaging of declarative memory in schizophrenia

The past three decades have seen tremendous growth in our understanding of the cerebral underpinnings of schizophrenia, including the neural correlates of the cognitive impairment seen in this syndrome. In this article we review the role that structural and functional neuroimaging has played in eluc...

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Bibliographic Details
Published in:Scandinavian journal of psychology 2001-07, Vol.42 (3), p.239-250
Main Authors: Weiss, Anthony, Heckers, Stephan
Format: Article
Language:English
Subjects:
Cerebellum - diagnostic imaging
Hippocampus - diagnostic imaging
Humans
Magnetic Resonance Imaging - methods
Memory
Memory Disorders - diagnostic imaging
Memory Disorders - physiopathology
Nerve Net - physiopathology
neuroimaging
Neuropsychological Tests
Prefrontal Cortex - diagnostic imaging
Prefrontal Cortex - physiopathology
Radionuclide Imaging - methods
Schizophrenia
Schizophrenia - diagnostic imaging
Schizophrenia - physiopathology
Schizophrenic Psychology
Thalamus - diagnostic imaging
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Summary:The past three decades have seen tremendous growth in our understanding of the cerebral underpinnings of schizophrenia, including the neural correlates of the cognitive impairment seen in this syndrome. In this article we review the role that structural and functional neuroimaging has played in elucidating the cerebral basis for the declarative memory deficits associated with schizophrenia. Memory impairment in schizophrenia appears to involve abnormal connectivity between the prefrontal cortex and three regions important in normal learning and memory: the hippocampus, thalamus, and cerebellum.
ISSN:0036-5564
1467-9450
DOI:10.1111/1467-9450.00234