Reduced Olfactory Bulb Volume in Patients With Schizophrenia

OBJECTIVE: The authors' goal in this study was to compare the size of olfactory bulbs of patients with schizophrenia and those of healthy subjects.METHOD: Magnetic resonance imaging scans of olfactory bulbs were obtained from 26 patients with schizophrenia and 22 healthy comparison subjects. A...

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Bibliographic Details
Published in:The American journal of psychiatry 2000-05, Vol.157 (5), p.828-830
Main Authors: Turetsky, Bruce I., Moberg, Paul J., Yousem, David M., Doty, Richard L., Arnold, Steven E., Gur, Raquel E.
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Biological and medical sciences
Discrimination (Psychology) - physiology
Female
Humans
Magnetic Resonance Imaging - statistics & numerical data
Male
Medical sciences
Middle Aged
Neurology
Odorants
Odors
Olfactory Bulb - anatomy & histology
Olfactory Bulb - physiology
Olfactory Bulb - physiopathology
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Schizophrenia
Schizophrenia - diagnosis
Schizophrenia - physiopathology
Sensory perception
Sensory Thresholds - physiology
Smell
Smell - physiology
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Summary:OBJECTIVE: The authors' goal in this study was to compare the size of olfactory bulbs of patients with schizophrenia and those of healthy subjects.METHOD: Magnetic resonance imaging scans of olfactory bulbs were obtained from 26 patients with schizophrenia and 22 healthy comparison subjects. A reliable region of interest procedure was used to measure olfactory bulb volume.RESULTS: Patients exhibited 23% smaller bilateral bulb volume than comparison subjects, independent of acute clinical, demographic, or treatment measures. Bulb volume correlated with odor detection sensitivity in healthy subjects but not in patients with schizophrenia.CONCLUSIONS: Patients with schizophrenia exhibit structural olfactory deficits as well as functional olfactory deficits. The olfactory system may be a model system in which to study the neurobiology of the disorder.
ISSN:0002-953X
1535-7228
DOI:10.1176/appi.ajp.157.5.828