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Opposite effects of nefazodone in two human models of anxiety

To explore further the role of serotonin (5-HT) in anxiety, the effects of the 5-HT reuptake inhibitor and 5-HT2A receptor antagonist nefazodone (NF) were measured in two human models of anxiety. Twenty-nine adult healthy volunteers of both sexes underwent conditioning of skin conductance responses...

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Bibliographic Details
Published in:Psychopharmacologia 2001-08, Vol.156 (4), p.454-460
Main Authors: SILVA, Marilei, HETEM, Luiz Alberto B, GUIMARAES, Francisco S, GRAEFF, Frederico G
Format: Article
Language:English
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Summary:To explore further the role of serotonin (5-HT) in anxiety, the effects of the 5-HT reuptake inhibitor and 5-HT2A receptor antagonist nefazodone (NF) were measured in two human models of anxiety. Twenty-nine adult healthy volunteers of both sexes underwent conditioning of skin conductance responses (CSCR) to a tone associated to an aversive white noise. Another 34 subjects performed a simulated public speaking (SPS) task, seemingly related to unconditioned fear. In both tests, subjective states were evaluated through the visual analogue mood scale (VAMS) and a bodily symptoms scale (BSS). In each experiment, subjects were randomly divided into three groups, which received 100 mg NF, 200 mg NF or placebo under double-blind condition. In the CSCR test, NF decreased the number of spontaneous fluctuations of skin conductance (F=4.94; df=2,26; P=0.015). In addition, the increase in VAMS anxiety factor induced by the conditioning task was attenuated by NF (F=11.11; df=2,26; P
ISSN:0033-3158
1432-2072
DOI:10.1007/s002130100752