Canalicular reticulum in vestibular hair cells

A membrane limited system referred to as canalicular reticulum (CR) has been demonstrated in the apical cytosol of the cochlea’s inner and outer hair cells. Similarities between cochlear and vestibular hair cells prompted investigation of the presence of CR in hair cells of the gerbil vestibular lab...

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Bibliographic Details
Published in:Hearing research 2000-05, Vol.143 (1), p.69-83
Main Authors: Cunningham, C.D., Weber, P.C., Spicer, S.S., Schulte, B.A.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Endoplasmic reticulum
Endoplasmic Reticulum - ultrastructure
Fundamental and applied biological sciences. Psychology
Gerbil
Gerbillinae
Golgi Apparatus - ultrastructure
Hair Cells, Auditory - ultrastructure
Inner ear
Ion transport
Membranogenesis
Microscopy, Electron
Mitochondria - ultrastructure
Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration
Space life sciences
Synaptic vesicle
Ultrastructure
Vertebrates: nervous system and sense organs
Vestibule, Labyrinth - ultrastructure
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Summary:A membrane limited system referred to as canalicular reticulum (CR) has been demonstrated in the apical cytosol of the cochlea’s inner and outer hair cells. Similarities between cochlear and vestibular hair cells prompted investigation of the presence of CR in hair cells of the gerbil vestibular labyrinth. A method of fixation with glutaraldehyde followed by an osmium–ferrocyanide mixture demonstrated abundant CR in the apex of both type I and type II hair cells. The CR was closely associated with numerous Golgi zones in the apex of the vestibular hair cells, indicating its genesis from Golgi cisternae. Also preserved in upper cytosol were discrete complexes of mitochondria with granular reticulum. These complexes offered a possible site for generating the membrane in Golgi zones and CR. Single and parallel cisternae of granular reticulum were observed in the basal half of the hair cells together with numerous synaptic-like vesicles. These cisternae with their terminal blebbing and accompanying canaliculi were interpreted as novel structures mediating synaptic vesicle genesis in vestibular hair cells in a manner comparable to that postulated for cochlear inner hair cells.
ISSN:0378-5955
1878-5891
DOI:10.1016/S0378-5955(00)00022-8