Adaptive Evolution on Neutral Networks

We study the evolution of large but finite asexual populations evolving in fitness landscapes in which all mutations are either neutral or strongly deleterious. We demonstrate that despite the absence of higher fitness genotypes, adaptation takes place as regions with more advantageous distributions...

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Bibliographic Details
Published in:Bulletin of mathematical biology 2001-07, Vol.63 (4), p.715-730
Main Author: Wilke, Claus O.
Format: Article
Language:English
Subjects:
Adaptation, Biological - genetics
Evolution & development
Evolution, Molecular
Models, Genetic
Mutation - genetics
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Summary:We study the evolution of large but finite asexual populations evolving in fitness landscapes in which all mutations are either neutral or strongly deleterious. We demonstrate that despite the absence of higher fitness genotypes, adaptation takes place as regions with more advantageous distributions of neutral genotypes are discovered. Since these discoveries are typically rare events, the population dynamics can be subdivided into separate epochs, with rapid transitions between them. Within one epoch, the average fitness in the population is approximately constant. The transitions between epochs, however, are generally accompanied by a significant increase in the average fitness. We verify our theoretical considerations with two analytically tractable bitstring models.
ISSN:0092-8240
1522-9602
DOI:10.1006/bulm.2001.0244