Time course and determinants of left ventricular function recovery after primary angioplasty in patients with acute myocardial infarction

OBJECTIVES We sought to evaluate the importance of time in relation to treatment, time course and determinants of recovery of left ventricular (LV) function in patients with acute myocardial infarction (AMI) undergoing primary percutaneous transluminal coronary angioplasty (PTCA). BACKGROUND Myocard...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2001-08, Vol.38 (2), p.464-471
Main Authors: Sheiban, Imad, Fragasso, Gabriele, Rosano, Giuseppe M.C, Dharmadhikari, Aniruddha, Tzifos, Vaios, Pagnotta, Paolo, Chierchia, Sergio L, Trevi, Gianpaolo
Format: Article
Language:English
Subjects:
Angioplasty, Balloon, Coronary
Biological and medical sciences
Cardiology. Vascular system
Coronary Angiography
Coronary heart disease
Creatine Kinase - metabolism
Creatine Kinase, MB Form
Female
Follow-Up Studies
Heart
Humans
Isoenzymes - metabolism
Kinetics
Male
Medical sciences
Middle Aged
Myocardial Infarction - enzymology
Myocardial Infarction - physiopathology
Myocardial Infarction - therapy
Myocardium - enzymology
Time Factors
Vascular Patency
Ventricular Function, Left
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Summary:OBJECTIVES We sought to evaluate the importance of time in relation to treatment, time course and determinants of recovery of left ventricular (LV) function in patients with acute myocardial infarction (AMI) undergoing primary percutaneous transluminal coronary angioplasty (PTCA). BACKGROUND Myocardial salvage has been shown to be dependent on the time elapsed from the onset of AMI to reperfusion. METHODS Left ventricular function was evaluated at hospital admission, after angioplasty, at 24 h and 6 months by both echocardiography and angiography and at 1, 7, 30, 90 and 180 days by echocardiography in 101 consecutive patients. RESULTS Patients were allocated to three groups according to interval between symptom onset and angioplasty: 4 h (group C). Patients in groups A and B showed a progressive improvement of LV function between day 7 and day 90, which became statistically significant at day 30 (p < 0.01). No LV function changes were noted in group C patients. Thrombolysis In Myocardial Infarction (TIMI) flow grade
ISSN:0735-1097
1558-3597
DOI:10.1016/S0735-1097(01)01407-3