His electrogram alternans reveal dual-wavefront inputs into and longitudinal dissociation within the bundle of his

His electrogram (HE) amplitude and morphology changes were observed in our previous studies during transition from "fast" to "slow" atrioventricular nodal (AVN) conduction. This phenomenon and its significance for the dual-AVN electrophysiology are not well recognized and have no...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2001-08, Vol.104 (7), p.832-838
Main Authors: YOUHUA ZHANG, BHARATI, Saroja, MOWREY, Kent A, SHAOWEI ZHUANG, TCHOU, Patrick J, MAZGALEV, Todor N
Format: Article
Language:English
Subjects:
Action Potentials - physiology
Animals
Atrioventricular Node - anatomy & histology
Atrioventricular Node - physiology
Biological and medical sciences
Bundle of His - physiology
Cardiac Pacing, Artificial
Electric Stimulation
Electrocardiography - methods
Electrocardiography. Vectocardiography
Electrodiagnosis. Electric activity recording
Electrophysiologic Techniques, Cardiac - methods
Heart Conduction System - physiology
Heart Rate - physiology
In Vitro Techniques
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Microelectrodes
Rabbits
Reaction Time - physiology
Temperature
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Summary:His electrogram (HE) amplitude and morphology changes were observed in our previous studies during transition from "fast" to "slow" atrioventricular nodal (AVN) conduction. This phenomenon and its significance for the dual-AVN electrophysiology are not well recognized and have not been studied. Experiments were performed on 17 healthy rabbit atrial-AVN preparations during standard programmed electrical pacing. HEs were mapped along the His bundle with roving surface electrodes, along with recording of cellular action potentials (APs). HEs recorded from the superior margin of the His bundle were of greater amplitude during basic beats and decreased substantially, by 42+/-19% (P
ISSN:0009-7322
1524-4539
DOI:10.1161/hc3301.092804