Segregation analysis of serum uric acid in the NHLBI Family Heart Study

Segregation analysis was performed on the serum uric acid measurements from 523 randomly ascertained Caucasian families from the NHLBI Family Heart Study. Gender-specific standardized residuals were used as the phenotypic variable in both familial correlation and segregation analysis. Uric acid resi...

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Bibliographic Details
Published in:Human genetics 2000-03, Vol.106 (3), p.355-359
Main Authors: WILK, J. B, DJOUSSE, L, BORECKI, I, ATWOOD, L. D, HUNT, S. C, RICH, S. S, ECKFELDT, J. H, ARNETT, D. K, RAO, D. C, MYERS, R. H
Format: Article
Language:English
Subjects:
Arteriosclerosis - epidemiology
Arteriosclerosis - genetics
Biological and medical sciences
Cardiology. Vascular system
Cohort Studies
Coronary Disease - blood
Coronary Disease - epidemiology
Coronary Disease - genetics
Coronary heart disease
European Continental Ancestry Group
Female
Heart
Humans
Male
Medical sciences
Middle Aged
Models, Genetic
Nuclear Family
Parents
Risk Factors
Statistics as Topic
Uric Acid - blood
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Summary:Segregation analysis was performed on the serum uric acid measurements from 523 randomly ascertained Caucasian families from the NHLBI Family Heart Study. Gender-specific standardized residuals were used as the phenotypic variable in both familial correlation and segregation analysis. Uric acid residuals were adjusted for age, age2, age3, body mass index (kg/m2), creatinine level, aspirin use (yes/no), total drinks (per week), HOMA insulin resistance index [(glucose * insulin)/22.5], diuretic use (yes/no), and triglyceride level. Sibling correlations (r=0.193) and parent-offspring correlations (r=0.217) were significantly different from zero, but these two familial correlations were not significantly different from one another. After adjustment for covariates, the heritability estimate for serum uric acid was 0.399. Segregation analysis rejected the "no major gene" model but was unable to discriminate between an "environmental" and a "Mendelian major gene" model. These results support the hypothesis that uric acid is a multifactorial trait possibly influenced by more than one major gene, modifying genes, and environmental factors.
ISSN:0340-6717
1432-1203
DOI:10.1007/s004390000243