Effect of R-(-)-α-methylhistamine and thioperamide on in vivo release of norepinephrine in the rat hippocampus

1. 1. The modifications of hippocampal release of norepinephrine following the administration of R-(-)-α-methylhistamine and thioperamide, respectively agonist and antagonist of histamine H 3 receptors, were assessed in freely moving rats by microdialysis. 2. 2. Both the systemic (2 mg/kg i.p.) and...

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Bibliographic Details
Published in:Progress in neuro-psychopharmacology & biological psychiatry 2000-02, Vol.24 (2), p.275-284
Main Authors: Di Carlo, Giovanni, Ghi, Piera, Orsetti, Marco
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cell receptors
Cell structures and functions
Dose-Response Relationship, Drug
Fundamental and applied biological sciences. Psychology
hippocampus
Hippocampus - drug effects
Hippocampus - physiology
Histamine Antagonists - administration & dosage
Histamine Antagonists - pharmacology
Male
Medical sciences
Memory - drug effects
Methylhistamines - administration & dosage
Methylhistamines - pharmacology
microdialysis
Miscellaneous
Molecular and cellular biology
Monoamines receptors (catecholamine, serotonine, histamine, acetylcholine)
Neuropharmacology
Neurotransmitters. Neurotransmission. Receptors
norepinephrine
Norepinephrine - metabolism
Pharmacology. Drug treatments
Piperidines - administration & dosage
Piperidines - pharmacology
Rats
Rats, Wistar
Receptors, Histamine - physiology
thioperamide
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Summary:1. 1. The modifications of hippocampal release of norepinephrine following the administration of R-(-)-α-methylhistamine and thioperamide, respectively agonist and antagonist of histamine H 3 receptors, were assessed in freely moving rats by microdialysis. 2. 2. Both the systemic (2 mg/kg i.p.) and local (100 μM via the probe) administration of thioperamide caused no modifications of basal release, indicating that the histaminergic system is not tonically involved in regulating the hippocampal noradrenergic activity. 3. 3. R-(-)-α-methylhistamine (1 and 100 μM) produced a slight, short-lasting and dose-dependent reduction of norepinephrine release antagonized by local perfusion (100 μM) and prevented by systemic administration of thioperamide 2 mg/kg. 4. 4. The results seem to indicate that the modulation of norepinephrine release through presynaptic H 3-receptors in the rat hippocampus plays a minor role in the memory-enhancing effects of thioperamide.
ISSN:0278-5846
1878-4216
DOI:10.1016/S0278-5846(99)00093-7