Methamphetamine Rapidly Decreases Vesicular Dopamine Uptake

: Vesicular sequestration is important in the regulation of cytoplasmic concentrations of monoamines such as dopamine. Moreover, recent evidence suggests that increases in cytoplasmic dopamine levels, perhaps attributable to changes in vesicular monoamine transporter function, contribute to methamph...

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Bibliographic Details
Published in:Journal of neurochemistry 2000-05, Vol.74 (5), p.2221-2223
Main Authors: Brown, Jeffrey M., Hanson, Glen R., Fleckenstein, Annette E.
Format: Article
Language:English
Subjects:
Animals
Corpus Striatum - cytology
Corpus Striatum - metabolism
Dopamine - pharmacokinetics
Dopamine uptake
Dopamine Uptake Inhibitors - pharmacology
Dose-Response Relationship, Drug
Male
Membrane Glycoproteins - metabolism
Membrane Transport Proteins
Methamphetamine
Methamphetamine - pharmacology
Neurons - metabolism
Neuropeptides
p-Chloroamphetamine - pharmacology
Rats
Rats, Sprague-Dawley
Serotonin Antagonists - pharmacology
Striatum
Synaptic vesicles
Synaptic Vesicles - metabolism
Tetrabenazine - analogs & derivatives
Tetrabenazine - metabolism
Vesicular Biogenic Amine Transport Proteins
Vesicular Monoamine Transport Proteins
Vesicular monoamine transporter
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Summary:: Vesicular sequestration is important in the regulation of cytoplasmic concentrations of monoamines such as dopamine. Moreover, recent evidence suggests that increases in cytoplasmic dopamine levels, perhaps attributable to changes in vesicular monoamine transporter function, contribute to methamphetamine‐induced dopaminergic deficits. Hence, we examined whether striatal vesicular uptake is altered following methamphetamine treatment. Multiple administrations of methamphetamine rapidly (within 1 h) decreased vesicular dopamine uptake and dihydrotetrabenazine binding, an effect that (a) persisted at least 24 h, (b) was associated with dopamine and not serotonin neurons, and (c) was unrelated to residual drug introduced by the original methamphetamine treatment. These data suggest that methamphetamine rapidly decreases vesicular monoamine transporter function in dopaminergic neurons, a phenomenon that may be associated with the long‐term damage caused by this stimulant.
ISSN:0022-3042
1471-4159
DOI:10.1046/j.1471-4159.2000.0742221.x