A comparison of endothelial function in Caucasian and Chinese women before and after the menopause

Objective: Arterial endothelial dysfunction is a key atherogenic event that may be related to oestrogen status. We therefore aimed to compare menopause-related changes in endothelial physiology in Chinese and Caucasian females. Methods: We studied 40 female subjects; 20 Chinese from a rural region o...

Full description

Saved in:
Bibliographic Details
Published in:Maturitas 2000-04, Vol.35 (1), p.31-37
Main Authors: McCrohon, J.A, Woo, Kam S, Celermajer, David S
Format: Article
Language:English
Subjects:
Adult
Aged
Asian Continental Ancestry Group
Australia
Biological and medical sciences
Blood Pressure
Brachial Artery - diagnostic imaging
Brachial Artery - physiology
Caucasian
China
Chinese
Endothelial function
Endothelium, Vascular - physiology
European Continental Ancestry Group
Female
Gynecology. Andrology. Obstetrics
Humans
Lipids - blood
Medical sciences
Menopause
Menopause - physiology
Middle Aged
Nitroglycerin - pharmacology
Postmenopause - physiology
Puberal and climacteric disorders (male and female)
Ultrasonography
Vasodilation - physiology
Vasodilator Agents - pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective: Arterial endothelial dysfunction is a key atherogenic event that may be related to oestrogen status. We therefore aimed to compare menopause-related changes in endothelial physiology in Chinese and Caucasian females. Methods: We studied 40 female subjects; 20 Chinese from a rural region of Southern China (ten premenopausal, aged 20–35 years, and ten postmenopausal, aged 55–66 years), and 20 age-matched Caucasian females from Sydney, Australia. All women had a clinical history, resting blood pressure and fasting lipids measured, and endothelial function assessed. Using high-resolution external vascular ultrasound, brachial artery diameter was measured at rest, after flow increase (causing endothelium-dependent dilatation) and after sublingual glyceryl trinitrate (GTW) (an endothelium-independent dilator). Results: There was a significant decline in endothelium-dependent dilatation (EDD) comparing Caucasian females from the premenopausal versus postmenopausal groups (8.4±2.7% versus 2.7±2.9%; P
ISSN:0378-5122
1873-4111
DOI:10.1016/S0378-5122(00)00102-X