INFLUENCE OF THE MENSTRUAL CYCLE ON THE LPS-INDUCED CYTOKINE RESPONSE OF MONOCYTES

We previously observed a gender difference in the cytokine response of peripheral blood monocytes (PBM). The study was performed to find out whether the gender-related difference might be due to hormonal changes during the menstrual cycle in healthy premenopausal females. The release of tumour necro...

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Bibliographic Details
Published in:Cytokine (Philadelphia, Pa.) Pa.), 2000-04, Vol.12 (4), p.413-416
Main Authors: Schwarz, E, Schäfer, C, Bode, J.C, Bode, C
Format: Article
Language:English
Subjects:
Adult
Aged
Cells, Cultured
cytokine response/gender/menstrual cycle/monocytes/tumour necrosis factor-α
Female
Humans
Interleukin-1 - biosynthesis
Interleukin-6 - biosynthesis
Lipopolysaccharides - immunology
Lipopolysaccharides - pharmacology
Male
Menstrual Cycle - immunology
Menstrual Cycle - physiology
Middle Aged
Monocytes - cytology
Monocytes - drug effects
Monocytes - immunology
Tumor Necrosis Factor-alpha - biosynthesis
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Summary:We previously observed a gender difference in the cytokine response of peripheral blood monocytes (PBM). The study was performed to find out whether the gender-related difference might be due to hormonal changes during the menstrual cycle in healthy premenopausal females. The release of tumour necrosis factor α (TNF-α) was reduced in the premenopausal females during the luteal phase compared to the follicular phase. Compared to the male controls the release of TNF-α and of interleukin 6 (IL-6) during the luteal phase was also diminished. In premenopausal females the concentration of estradiol in plasma correlated with the release of TNF-α and IL-6 during the luteal phase.
ISSN:1043-4666
1096-0023
DOI:10.1006/cyto.1999.0570