Increased striatal dopamine transporter in adult patients with attention deficit hyperactivity disorder: effects of methylphenidate as measured by single photon emission computed tomography

Ten previously untreated adults with attention deficit hyperactivity disorder (ADHD) were investigated before and after 4 weeks of treatment with a dose of 3×5 mg methylphenidate/d by single photon emission computed tomography (SPECT) with [Tc–99m]TRODAT-1, the first Tc-99m labelled SPECT ligand spe...

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Bibliographic Details
Published in:Neuroscience letters 2000-05, Vol.285 (2), p.107-110
Main Authors: Krause, Klaus-Henning, Dresel, Stefan H, Krause, Johanna, Kung, Hank F, Tatsch, Klaus
Format: Article
Language:English
Subjects:
Adult
Attention Deficit Disorder with Hyperactivity - diagnostic imaging
Attention Deficit Disorder with Hyperactivity - drug therapy
Attention Deficit Disorder with Hyperactivity - metabolism
Attention deficit hyperactivity disorder
Biological and medical sciences
Carrier Proteins - metabolism
Corpus Striatum - chemistry
Corpus Striatum - drug effects
Corpus Striatum - pathology
Dopamine Plasma Membrane Transport Proteins
Dopamine transporter
Female
Humans
Male
Medical sciences
Membrane Glycoproteins
Membrane Transport Proteins
Methylphenidate
Methylphenidate - administration & dosage
Methylphenidate - pharmacology
Methylphenidate - therapeutic use
Middle Aged
Nerve Tissue Proteins
Neuropharmacology
Organotechnetium Compounds
Pharmacology. Drug treatments
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Radiography
Radiopharmaceuticals
Single photon emission computed tomography
Tomography, Emission-Computed, Single-Photon
TRODAT-1
Tropanes
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Summary:Ten previously untreated adults with attention deficit hyperactivity disorder (ADHD) were investigated before and after 4 weeks of treatment with a dose of 3×5 mg methylphenidate/d by single photon emission computed tomography (SPECT) with [Tc–99m]TRODAT-1, the first Tc-99m labelled SPECT ligand specifically binding to the dopamine transporter (DAT). For semiquantitative evaluation of the DAT, specific binding ([STR–BKG]/BKG) was calculated in the striatum (STR) with the cerebellum used as background (BKG). The patients with ADHD presented with increased specific binding of Tc-99m-TRODAT-1 to the DAT as compared with age and sex matched controls ([STR–BKG]/BKG 1.43±0.18 vs. 1.22±0.05, P
ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(00)01040-5