Study of the expression of CD68+ macrophages and CD8+ T cells in human granulomas and periapical cysts

In the periapex, the interaction among inflammatory cells and microorganisms and their products results both in specific and nonspecific immune responses. Many studies have reported quantitative analysis of the immunocompetent cells in periapical lesions, but the exact ratio of these cells in cysts...

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Published in:Oral surgery, oral medicine, oral pathology, oral radiology and endodontics oral medicine, oral pathology, oral radiology and endodontics, 2001-08, Vol.92 (2), p.221-227
Main Authors: de Oliveira Rodini, Camila, Lara, Vanessa Soares
Format: Article
Language:English
Subjects:
Antibodies, Monoclonal
Antigens, CD - analysis
Antigens, Differentiation, Myelomonocytic - analysis
Biological and medical sciences
CD8 Antigens - analysis
CD8-Positive T-Lymphocytes - pathology
Cell Count
Chi-Square Distribution
Coloring Agents
Dentistry
Disease Progression
Facial bones, jaws, teeth, parodontium: diseases, semeiology
Humans
Immunoenzyme Techniques
Lymphocyte Count
Macrophages - pathology
Medical sciences
Otorhinolaryngology. Stomatology
Periapical Granuloma - immunology
Periapical Granuloma - pathology
Radicular Cyst - immunology
Radicular Cyst - pathology
Tumors
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Summary:In the periapex, the interaction among inflammatory cells and microorganisms and their products results both in specific and nonspecific immune responses. Many studies have reported quantitative analysis of the immunocompetent cells in periapical lesions, but the exact ratio of these cells in cysts and granulomas remains unknown. In the present study, we undertook a quantitative analysis of CD68+ cells and CD8+ T cells in human periapical granulomas and cysts. Immunoperoxidase staining revealed that CD68+ cells were present in both lesions, with no statistically significant difference, mainly distributed in the inner portion of the lesion, where the inflammation site is more active. On the other hand, CD8+ lymphocytes were more numerous in cysts. Thus, it appears that CD8+ T cells may play a more important role in a later phase of periapical lesion progression, probably exerting regulatory or cytotoxic functions in cellular immune response, which may lead to the stabilization of these lesions. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001;92:221-7)
ISSN:1079-2104
1528-395X
DOI:10.1067/moe.2001.116813