Differential jejunal and colonic adaptation due to resection and IGF-I in parenterally fed rats

Patients with severe short-bowel syndrome (SBS) often require long-term total parenteral nutrition (TPN) to maintain their nutritional status because of limited intestinal adaptation. Growth factors, including insulin-like growth factor I (IGF-I), are under investigation to promote intestinal adapta...

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Bibliographic Details
Published in:American journal of physiology: Gastrointestinal and liver physiology 2000-05, Vol.278 (5), p.G700-G709
Main Authors: Gillingham, M B, Dahly, E M, Carey, H V, Clark, M D, Kritsch, K R, Ney, D M
Format: Article
Language:English
Subjects:
Acclimatization
Analysis of Variance
Animals
Body Weight
Colon - drug effects
Colon - physiology
Colon - surgery
Humans
Insulin-Like Growth Factor I - pharmacology
Intestinal Mucosa - cytology
Intestinal Mucosa - drug effects
Intestinal Mucosa - physiology
Jejunum - drug effects
Jejunum - physiology
Jejunum - surgery
Male
Nutritional Status
Parenteral Nutrition, Total
Rats
Rats, Sprague-Dawley
Recombinant Proteins - pharmacology
Short Bowel Syndrome - physiopathology
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Summary:Patients with severe short-bowel syndrome (SBS) often require long-term total parenteral nutrition (TPN) to maintain their nutritional status because of limited intestinal adaptation. Growth factors, including insulin-like growth factor I (IGF-I), are under investigation to promote intestinal adaptation and tolerance to oral feeding. We investigated structural and functional adaptation of the jejunum and colon in four groups of rats maintained with TPN for 7 days after a 60% jejunoileal resection and cecectomy or sham surgery and treatment with IGF-I or vehicle. Resection alone did not stimulate jejunal growth. IGF-I significantly increased jejunal mucosal mass, enterocyte proliferation, and migration rates. IGF-I decreased jejunal sucrase specific activity and reduced active ion transport and ionic permeability; resection alone had no effect. In contrast, resection significantly increased colonic mass and crypt depth but had no effect on active ion transport or ionic permeability. IGF-I had minimal effects on colonic structure. IGF-I but not resection stimulates jejunal adaptation, whereas resection but not IGF-I stimulates colonic growth in rats subjected to a model for human SBS. IGF-I treatment may improve intestinal adaptation in humans with SBS.
ISSN:0193-1857
1522-1547
DOI:10.1152/ajpgi.2000.278.5.G700