The effect of cisapride on total parenteral nutrition-associated cholestasis in rats

Cholestasis is a frequent problem in patients on total parenteral nutrition. Cisapride has a prokinetic effect on the biliary system, but its effect on hepatic excretory function is unknown. To study the effect of cisapride on TPN-induced cholestasis in a rat model. Bile flow and bile salt secretion...

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Published in:The Israel Medical Association journal 2000-02, Vol.2 (2), p.91-93
Main Authors: Zahavi, I, Rosezki, O, Stolkarts, Y, Shamir, R, Heckelman, B, Marcus, H, Dinari, G
Format: Article
Language:English
Subjects:
Animals
Bile Acids and Salts - secretion
Cholestasis - etiology
Cholestasis - prevention & control
Cisapride - therapeutic use
Gastrointestinal Agents - therapeutic use
Male
Parenteral Nutrition - adverse effects
Rats
Rats, Wistar
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container_issue 2
container_start_page 91
container_title The Israel Medical Association journal
container_volume 2
creator Zahavi, I
Rosezki, O
Stolkarts, Y
Shamir, R
Heckelman, B
Marcus, H
Dinari, G
description Cholestasis is a frequent problem in patients on total parenteral nutrition. Cisapride has a prokinetic effect on the biliary system, but its effect on hepatic excretory function is unknown. To study the effect of cisapride on TPN-induced cholestasis in a rat model. Bile flow and bile salt secretion rate were measured in rats given TPN. There were four groups of 8 to 13 animals each. After a one hour baseline period during which all four groups received i.v. saline infusion, two groups received a TPN solution for another 2 hours, while saline was infused in the two control groups. At the beginning of the second hour, 2 mg/kg cisapride was injected i.v. as a bolus into one experimental and one control group. Bile was collected from the common bile duct. At the end of the third hour, TPN caused a significant reduction in bile flow (P < 0.02) and bile salt secretion rate (P < 0.001) (61.24 vs. 50.74 microliters/min/kg, and 1.173 vs. 0.799 mumol/min/kg, respectively). Addition of cisapride abolished the cholestatic effect of TPN. Cisapride has a protective effect against TPN-associated cholestasis. This may have clinical significance, and further studies are warranted.
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Cisapride has a prokinetic effect on the biliary system, but its effect on hepatic excretory function is unknown. To study the effect of cisapride on TPN-induced cholestasis in a rat model. Bile flow and bile salt secretion rate were measured in rats given TPN. There were four groups of 8 to 13 animals each. After a one hour baseline period during which all four groups received i.v. saline infusion, two groups received a TPN solution for another 2 hours, while saline was infused in the two control groups. At the beginning of the second hour, 2 mg/kg cisapride was injected i.v. as a bolus into one experimental and one control group. Bile was collected from the common bile duct. At the end of the third hour, TPN caused a significant reduction in bile flow (P &lt; 0.02) and bile salt secretion rate (P &lt; 0.001) (61.24 vs. 50.74 microliters/min/kg, and 1.173 vs. 0.799 mumol/min/kg, respectively). Addition of cisapride abolished the cholestatic effect of TPN. 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subjects Animals
Bile Acids and Salts - secretion
Cholestasis - etiology
Cholestasis - prevention & control
Cisapride - therapeutic use
Gastrointestinal Agents - therapeutic use
Male
Parenteral Nutrition - adverse effects
Rats
Rats, Wistar
title The effect of cisapride on total parenteral nutrition-associated cholestasis in rats
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