Dynamic laser speckle pattern in monitoring of local deformation of tablet surface after compression

A method and a sensor device were developed to detect dynamic laser speckle pattern for monitoring of deformation of pharmaceutical tablets after compression. Temporal variations in optical signal revealed local surface deformation of the ibuprofen and the starch acetate tablets as well as anisotrop...

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Bibliographic Details
Published in:International journal of pharmaceutics 2000-04, Vol.199 (2), p.205-208
Main Authors: Silvennoinen, Raimo, Hyvärinen, Ville, Raatikainen, Pasi, Peiponen, Kai-Erik
Format: Article
Language:English
Subjects:
Capsules
Chemistry, Pharmaceutical - methods
Chemistry, Pharmaceutical - standards
Dynamic laser speckle
Ibuprofen
Ibuprofen - administration & dosage
Lasers
Starch - analogs & derivatives
Starch acetate
Tablet compression
Temporal relaxation
Time Factors
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Summary:A method and a sensor device were developed to detect dynamic laser speckle pattern for monitoring of deformation of pharmaceutical tablets after compression. Temporal variations in optical signal revealed local surface deformation of the ibuprofen and the starch acetate tablets as well as anisotropy of tablet surfaces at the inspection location.
ISSN:0378-5173
1873-3476
DOI:10.1016/S0378-5173(00)00384-7