Serum elastase activity is elevated in migraine

Migraine has been associated with diseases considered to be related to extracellular matrix disorders—in particular, cervical artery dissection. In this population‐based study, we found a highly significant association between migraine and the activity of serum elastase, a metalloendopeptidase degra...

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Bibliographic Details
Published in:Annals of neurology 2000-05, Vol.47 (5), p.648-651
Main Authors: Tzourio, Christophe, El Amrani, Mohamed, Robert, Ladislas, Alpérovitch, Annick
Format: Article
Language:English
Subjects:
Aged
Analysis of Variance
Biological and medical sciences
Female
Humans
Leukocyte Elastase - blood
Male
Medical sciences
Migraine Disorders - enzymology
Migraine Disorders - physiopathology
Neurology
Serine Endopeptidases - blood
Vascular diseases and vascular malformations of the nervous system
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Summary:Migraine has been associated with diseases considered to be related to extracellular matrix disorders—in particular, cervical artery dissection. In this population‐based study, we found a highly significant association between migraine and the activity of serum elastase, a metalloendopeptidase degrading specific elastin‐type amino acid sequences. Such enzymes are involved in matrix degradation. This association was seen in both sexes and was stronger for migraine with aura. These findings could help in the understanding of why patients with migraine are at higher risk of stroke. Further study is needed to establish whether extracellular matrix abnormalities play a broader role in the pathophysiology of migraine. Ann Neurol 2000;47:648–651
ISSN:0364-5134
1531-8249
DOI:10.1002/1531-8249(200005)47:5<648::AID-ANA14>3.0.CO;2-5