Insulin-Enhancing Vanadium(III) Complexes

Simple, high-yield, large-scale syntheses of the V(III) complexes tris(maltolato)vanadium(III), V(ma)3, tris(ethylmaltolato)vanadium(III), V(ema)3, tris(kojato)vanadium(III) monohydrate, V(koj)3·H2O, and tris(1,2-dimethyl-3-hydroxy-4-pyridinonato)vanadium(III) dodecahydrate, V(dpp)3·12H2O, are descr...

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Bibliographic Details
Published in:Inorganic chemistry 2001-08, Vol.40 (18), p.4686-4690
Main Authors: Melchior, Marco, Rettig, Steven J., Liboiron, Barry D., Thompson, Katherine H., Yuen, Violet G., McNeill, John H., Orvig, Chris
Format: Article
Language:English
Subjects:
Animals
Crystallography, X-Ray
Diabetes Mellitus, Experimental - drug therapy
Diabetes Mellitus, Experimental - metabolism
Hypoglycemic Agents - chemistry
Hypoglycemic Agents - therapeutic use
Indicators and Reagents
Insulin - metabolism
Ligands
Male
Models, Molecular
Organometallic Compounds - chemistry
Organometallic Compounds - therapeutic use
Oxidation-Reduction
Pyridones - chemistry
Pyridones - therapeutic use
Pyrones - chemistry
Pyrones - therapeutic use
Rats
Rats, Wistar
Spectrophotometry, Infrared
Thermodynamics
Vanadium
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Summary:Simple, high-yield, large-scale syntheses of the V(III) complexes tris(maltolato)vanadium(III), V(ma)3, tris(ethylmaltolato)vanadium(III), V(ema)3, tris(kojato)vanadium(III) monohydrate, V(koj)3·H2O, and tris(1,2-dimethyl-3-hydroxy-4-pyridinonato)vanadium(III) dodecahydrate, V(dpp)3·12H2O, are described; the characterization of these complexes by various methods and, in the case of V(dpp)3·12H2O, by an X-ray crystal structure determination, is reported. The ability of these complexes to normalize glucose levels in the STZ-diabetic rat model has been examined and compared with that of the benchmark compound BMOV (bis(maltolato)oxovanadium(IV)), an established insulin-enhancing agent.
ISSN:0020-1669
1520-510X
DOI:10.1021/ic000984t