How to activate p53

The tumour suppressor protein p53 is stabilised and activated in response to ionising radiation. This is known to depend on the kinase ATM; recent results suggest ATM acts via the downstream kinase Chk2/hCds1, which stabilises p53 at least in part by direct phosphorylation of residue serine 20.

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Bibliographic Details
Published in:Current biology 2000-04, Vol.10 (8), p.R315-R317
Main Author: Caspari, T
Format: Article
Language:English
Subjects:
Ataxia Telangiectasia Mutated Proteins
Binding Sites
Cell Cycle Proteins - metabolism
Checkpoint Kinase 1
Checkpoint Kinase 2
DNA Damage
DNA-Binding Proteins
Humans
Nuclear Proteins
Phosphorylation - radiation effects
Protein Kinases - metabolism
Protein-Serine-Threonine Kinases - metabolism
Proto-Oncogene Proteins - metabolism
Proto-Oncogene Proteins c-mdm2
Tumor Suppressor Protein p53 - metabolism
Tumor Suppressor Proteins
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Description
Summary:The tumour suppressor protein p53 is stabilised and activated in response to ionising radiation. This is known to depend on the kinase ATM; recent results suggest ATM acts via the downstream kinase Chk2/hCds1, which stabilises p53 at least in part by direct phosphorylation of residue serine 20.
ISSN:0960-9822