Effects of short-term estrogen treatment on the neointimal response to balloon injury of rat carotid artery

This study tested the hypothesis that estrogen inhibits the response to balloon injury of the rat carotid artery by modulating molecular events occurring early (72 hours) in the postinjury period. Short-term estrogen treatment beginning on the day of injury and continuing for 3 days reduced neointim...

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Bibliographic Details
Published in:The American journal of cardiology 2000-05, Vol.85 (10), p.1276-1279
Main Authors: Mori, Tatsuhiko, Durand, Joan, Chen, Yiu-Fai, Thompson, J.Anthony, Bakir, Stephen, Oparil, Suzanne
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
Body Weight - drug effects
Cardiovascular disease
Carotid Artery Injuries - drug therapy
Carotid Artery Injuries - etiology
Catheterization - adverse effects
Estradiol - therapeutic use
Estrogens
Female
Organ Size - drug effects
Ovariectomy
Rats
Rats, Sprague-Dawley
Sex Characteristics
Therapy
Tunica Intima - drug effects
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Summary:This study tested the hypothesis that estrogen inhibits the response to balloon injury of the rat carotid artery by modulating molecular events occurring early (72 hours) in the postinjury period. Short-term estrogen treatment beginning on the day of injury and continuing for 3 days reduced neointima formation by 60%, indicating that estrogen protects injured blood vessels by perturbing cellular and/or molecular events occurring early in the injury response.
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(00)00748-7