The Gas-Phase Chemistry of Cyclodextrin Inclusion Complexes

Complexes of cyclodextrins with amino acid analytes are produced in the gas phase and are ideal for the study of molecular recognition. In this Account, we discuss the evidence for the presence of gas-phase inclusion complexes and the nature of the interaction. The use of cyclodextrins as chiral sel...

Full description

Saved in:
Bibliographic Details
Published in:Accounts of chemical research 2001-08, Vol.34 (8), p.653-661
Main Author: Lebrilla, Carlito B
Format: Article
Language:English
Subjects:
Carbohydrate Sequence
Cyclodextrins - chemistry
Gases
Models, Molecular
Pharmaceutical Preparations - chemistry
Stereoisomerism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Complexes of cyclodextrins with amino acid analytes are produced in the gas phase and are ideal for the study of molecular recognition. In this Account, we discuss the evidence for the presence of gas-phase inclusion complexes and the nature of the interaction. The use of cyclodextrins as chiral selectors in gas-phase guest-exchange reactions is illustrated, and the nature of the enantioselectivity is discussed. The development of the enantioselective reaction into an analytical method for determining enantiomeric excess is also described.
ISSN:0001-4842
1520-4898
DOI:10.1021/ar980125x