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Nucleus Accumbens Amphetamine Microinjections Unconditionally Elicit 50-kHz Ultrasonic Vocalizations in Rats
The authors have hypothesized that, in adult rats, 50-kHz ultrasonic vocalizations (USVs) index a state characterized by high arousal and expectations of reward. This study was conducted to investigate whether dopamine agonism of the nucleus accumbens (NAcc) could evoke such an appetitive state, by...
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| Published in: | Behavioral neuroscience 2001-08, Vol.115 (4), p.940-944 |
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| container_end_page | 944 |
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| container_title | Behavioral neuroscience |
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| creator | Burgdorf, Jeffrey Knutson, Brian Panksepp, Jaak Ikemoto, Satoshi |
| description | The authors have hypothesized that, in adult rats, 50-kHz ultrasonic vocalizations (USVs) index a state characterized by high arousal and expectations of reward. This study was conducted to investigate whether dopamine agonism of the nucleus accumbens (NAcc) could evoke such an appetitive state, by examining the effects of NAcc amphetamine (AMPH) microinjections on USVs. Intra-NAcc AMPH injections (0.3, 1.0, 3.0, 10.0 μg unilaterally) produced robust, dose-dependent increases in 50-kHz USVs, which could not be accounted for by concomitant increases in locomotor activity (LA). However, AMPH injections into dorsal control caudate putamen sites produced a modest, dose-dependent increase in LA without significant increases in 50-kHz USVs. These findings indicate that NAcc AMPH microinjections selectively evoke 50-kHz USVs in rats, supporting the notion that dopamine elevations in the NAcc may unconditionally elicit a state of reward anticipation. |
| doi_str_mv | 10.1037/0735-7044.115.4.940 |
| format | article |
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This study was conducted to investigate whether dopamine agonism of the nucleus accumbens (NAcc) could evoke such an appetitive state, by examining the effects of NAcc amphetamine (AMPH) microinjections on USVs. Intra-NAcc AMPH injections (0.3, 1.0, 3.0, 10.0 μg unilaterally) produced robust, dose-dependent increases in 50-kHz USVs, which could not be accounted for by concomitant increases in locomotor activity (LA). However, AMPH injections into dorsal control caudate putamen sites produced a modest, dose-dependent increase in LA without significant increases in 50-kHz USVs. These findings indicate that NAcc AMPH microinjections selectively evoke 50-kHz USVs in rats, supporting the notion that dopamine elevations in the NAcc may unconditionally elicit a state of reward anticipation.</description><identifier>ISSN: 0735-7044</identifier><identifier>EISSN: 1939-0084</identifier><identifier>DOI: 10.1037/0735-7044.115.4.940</identifier><identifier>PMID: 11508733</identifier><identifier>CODEN: BENEDJ</identifier><language>eng</language><publisher>Washington, DC: American Psychological Association</publisher><subject>Amphetamine - administration & dosage ; Amphetamine - pharmacology ; Amphetamines ; Animal ; Animal Vocalizations ; Animals ; Appetitive Behavior - drug effects ; Behavioral psychophysiology ; Biological and medical sciences ; Central Nervous System Stimulants - administration & dosage ; Central Nervous System Stimulants - pharmacology ; Dopamine Agents - administration & dosage ; Dopamine Agents - pharmacology ; Fundamental and applied biological sciences. Psychology ; Male ; Microinjections ; Neurotransmission and behavior ; Nucleus Accumbens ; Nucleus Accumbens - drug effects ; Nucleus Accumbens - pathology ; Nucleus Accumbens - physiology ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Ultrasonics ; Vocalization, Animal - drug effects</subject><ispartof>Behavioral neuroscience, 2001-08, Vol.115 (4), p.940-944</ispartof><rights>2002 INIST-CNRS</rights><rights>Public Domain</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a456t-d58777702121a4726f222452f2d516205129f85f0262f55082bae62774ec52b53</citedby><cites>FETCH-LOGICAL-a456t-d58777702121a4726f222452f2d516205129f85f0262f55082bae62774ec52b53</cites><orcidid>0000-0002-0732-7386 ; 0000-0002-7669-426X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14135979$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11508733$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Gallagher, Michela</contributor><creatorcontrib>Burgdorf, Jeffrey</creatorcontrib><creatorcontrib>Knutson, Brian</creatorcontrib><creatorcontrib>Panksepp, Jaak</creatorcontrib><creatorcontrib>Ikemoto, Satoshi</creatorcontrib><title>Nucleus Accumbens Amphetamine Microinjections Unconditionally Elicit 50-kHz Ultrasonic Vocalizations in Rats</title><title>Behavioral neuroscience</title><addtitle>Behav Neurosci</addtitle><description>The authors have hypothesized that, in adult rats, 50-kHz ultrasonic vocalizations (USVs) index a state characterized by high arousal and expectations of reward. This study was conducted to investigate whether dopamine agonism of the nucleus accumbens (NAcc) could evoke such an appetitive state, by examining the effects of NAcc amphetamine (AMPH) microinjections on USVs. Intra-NAcc AMPH injections (0.3, 1.0, 3.0, 10.0 μg unilaterally) produced robust, dose-dependent increases in 50-kHz USVs, which could not be accounted for by concomitant increases in locomotor activity (LA). However, AMPH injections into dorsal control caudate putamen sites produced a modest, dose-dependent increase in LA without significant increases in 50-kHz USVs. These findings indicate that NAcc AMPH microinjections selectively evoke 50-kHz USVs in rats, supporting the notion that dopamine elevations in the NAcc may unconditionally elicit a state of reward anticipation.</description><subject>Amphetamine - administration & dosage</subject><subject>Amphetamine - pharmacology</subject><subject>Amphetamines</subject><subject>Animal</subject><subject>Animal Vocalizations</subject><subject>Animals</subject><subject>Appetitive Behavior - drug effects</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Central Nervous System Stimulants - administration & dosage</subject><subject>Central Nervous System Stimulants - pharmacology</subject><subject>Dopamine Agents - administration & dosage</subject><subject>Dopamine Agents - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Microinjections</subject><subject>Neurotransmission and behavior</subject><subject>Nucleus Accumbens</subject><subject>Nucleus Accumbens - drug effects</subject><subject>Nucleus Accumbens - pathology</subject><subject>Nucleus Accumbens - physiology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Ultrasonics</subject><subject>Vocalization, Animal - drug effects</subject><issn>0735-7044</issn><issn>1939-0084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNqFkc1q3DAUhUVoSCZpnyBQTCFZ1ZOrP8tehpCfQtJC6HQrZI1MNJVlV5IXk6evzAwNDYVqIxl95wqfD6EzDEsMVFyCoLwUwNgSY75ky4bBAVrghjYlQM3eocUf4hidxLgBAAaMH6HjHIBaULpA7uuknZlicaX11LfG51M_PpukeutN8Wh1GKzfGJ3skO9WXg9-becP5dy2uHFW21RwKH_evxQrl4KKg7e6-DFo5eyL2sWsL55Uiu_RYadcNB_2-yla3d58v74vH77dfbm-eigV41Uq17wWeQHBBCsmSNURQhgnHVlzXBHgmDRdzTsgFel4_hPSKlMRIZjRnLScnqKL3dwxDL8mE5PsbdTGOeXNMEUpcC6wzgX8D8SCUMzIPPHTG3AzTCF3EGWFGa1A1CxDdAflzmIMppNjsL0KW4lBzsrkLETOQmQ2IJnMynLq43701PZm_ZrZO8rA-R5QMZfaBeW1ja8cw5Q3osnc5x2nRiXHuNUqJJvlRj2FYHySrTd_vXv-b_wN9xvihLkV</recordid><startdate>20010801</startdate><enddate>20010801</enddate><creator>Burgdorf, Jeffrey</creator><creator>Knutson, Brian</creator><creator>Panksepp, Jaak</creator><creator>Ikemoto, Satoshi</creator><general>American Psychological Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7RZ</scope><scope>PSYQQ</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0732-7386</orcidid><orcidid>https://orcid.org/0000-0002-7669-426X</orcidid></search><sort><creationdate>20010801</creationdate><title>Nucleus Accumbens Amphetamine Microinjections Unconditionally Elicit 50-kHz Ultrasonic Vocalizations in Rats</title><author>Burgdorf, Jeffrey ; Knutson, Brian ; Panksepp, Jaak ; Ikemoto, Satoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a456t-d58777702121a4726f222452f2d516205129f85f0262f55082bae62774ec52b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Amphetamine - administration & dosage</topic><topic>Amphetamine - pharmacology</topic><topic>Amphetamines</topic><topic>Animal</topic><topic>Animal Vocalizations</topic><topic>Animals</topic><topic>Appetitive Behavior - drug effects</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Central Nervous System Stimulants - administration & dosage</topic><topic>Central Nervous System Stimulants - pharmacology</topic><topic>Dopamine Agents - administration & dosage</topic><topic>Dopamine Agents - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Microinjections</topic><topic>Neurotransmission and behavior</topic><topic>Nucleus Accumbens</topic><topic>Nucleus Accumbens - drug effects</topic><topic>Nucleus Accumbens - pathology</topic><topic>Nucleus Accumbens - physiology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Ultrasonics</topic><topic>Vocalization, Animal - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Burgdorf, Jeffrey</creatorcontrib><creatorcontrib>Knutson, Brian</creatorcontrib><creatorcontrib>Panksepp, Jaak</creatorcontrib><creatorcontrib>Ikemoto, Satoshi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PsycArticles (via ProQuest)</collection><collection>ProQuest One Psychology</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Behavioral neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Burgdorf, Jeffrey</au><au>Knutson, Brian</au><au>Panksepp, Jaak</au><au>Ikemoto, Satoshi</au><au>Gallagher, Michela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nucleus Accumbens Amphetamine Microinjections Unconditionally Elicit 50-kHz Ultrasonic Vocalizations in Rats</atitle><jtitle>Behavioral neuroscience</jtitle><addtitle>Behav Neurosci</addtitle><date>2001-08-01</date><risdate>2001</risdate><volume>115</volume><issue>4</issue><spage>940</spage><epage>944</epage><pages>940-944</pages><issn>0735-7044</issn><eissn>1939-0084</eissn><coden>BENEDJ</coden><abstract>The authors have hypothesized that, in adult rats, 50-kHz ultrasonic vocalizations (USVs) index a state characterized by high arousal and expectations of reward. This study was conducted to investigate whether dopamine agonism of the nucleus accumbens (NAcc) could evoke such an appetitive state, by examining the effects of NAcc amphetamine (AMPH) microinjections on USVs. Intra-NAcc AMPH injections (0.3, 1.0, 3.0, 10.0 μg unilaterally) produced robust, dose-dependent increases in 50-kHz USVs, which could not be accounted for by concomitant increases in locomotor activity (LA). However, AMPH injections into dorsal control caudate putamen sites produced a modest, dose-dependent increase in LA without significant increases in 50-kHz USVs. These findings indicate that NAcc AMPH microinjections selectively evoke 50-kHz USVs in rats, supporting the notion that dopamine elevations in the NAcc may unconditionally elicit a state of reward anticipation.</abstract><cop>Washington, DC</cop><pub>American Psychological Association</pub><pmid>11508733</pmid><doi>10.1037/0735-7044.115.4.940</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-0732-7386</orcidid><orcidid>https://orcid.org/0000-0002-7669-426X</orcidid></addata></record> |
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| subjects | Amphetamine - administration & dosage Amphetamine - pharmacology Amphetamines Animal Animal Vocalizations Animals Appetitive Behavior - drug effects Behavioral psychophysiology Biological and medical sciences Central Nervous System Stimulants - administration & dosage Central Nervous System Stimulants - pharmacology Dopamine Agents - administration & dosage Dopamine Agents - pharmacology Fundamental and applied biological sciences. Psychology Male Microinjections Neurotransmission and behavior Nucleus Accumbens Nucleus Accumbens - drug effects Nucleus Accumbens - pathology Nucleus Accumbens - physiology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Random Allocation Rats Rats, Sprague-Dawley Ultrasonics Vocalization, Animal - drug effects |
| title | Nucleus Accumbens Amphetamine Microinjections Unconditionally Elicit 50-kHz Ultrasonic Vocalizations in Rats |
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