The Partner of Inscuteable/Discs-Large Complex Is Required to Establish Planar Polarity during Asymmetric Cell Division in Drosophila

Frizzled (Fz) signaling regulates cell polarity in both vertebrates and invertebrates. In Drosophila, Fz orients the asymmetric division of the sensory organ precursor cell (pI) along the antero-posterior axis of the notum. Planar polarization involves a remodeling of the apical-basal polarity of th...

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Bibliographic Details
Published in:Cell 2001-08, Vol.106 (3), p.355-366
Main Authors: Bellaı̈che, Yohanns, Radovic, Anna, Woods, Daniel F., Hough, Colleen D., Parmentier, Marie-Laure, O'Kane, Cahir J., Bryant, Peter J., Schweisguth, François
Format: Article
Language:English
Subjects:
Animals
Body Patterning
Carrier Proteins - genetics
Carrier Proteins - metabolism
Cell Cycle Proteins
Cell Division
Cell Polarity
Drosophila
Drosophila melanogaster - cytology
Drosophila melanogaster - embryology
Drosophila melanogaster - genetics
Drosophila melanogaster - metabolism
Drosophila Proteins
Frizzled Receptors
Immunohistochemistry
Insect Proteins - genetics
Insect Proteins - metabolism
Intracellular Signaling Peptides and Proteins
Juvenile Hormones - metabolism
Macromolecular Substances
Membrane Proteins - physiology
Models, Biological
Mutation - genetics
Neurons - cytology
Neurons - metabolism
Precipitin Tests
Protein Binding
Protein Kinase C - metabolism
Protein Transport
Receptors, G-Protein-Coupled
Recombinant Fusion Proteins - metabolism
Signal Transduction
Stem Cells - cytology
Stem Cells - metabolism
Tumor Suppressor Proteins
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Summary:Frizzled (Fz) signaling regulates cell polarity in both vertebrates and invertebrates. In Drosophila, Fz orients the asymmetric division of the sensory organ precursor cell (pI) along the antero-posterior axis of the notum. Planar polarization involves a remodeling of the apical-basal polarity of the pI cell. The Discs-large (Dlg) and Partner of Inscuteable (Pins) proteins accumulate at the anterior cortex, while Bazooka (Baz) relocalizes to the posterior cortex. Dlg interacts directly with Pins and regulates the localization of Pins and Baz. Pins acts with Fz to localize Baz posteriorly, but Baz is not required to localize Pins anteriorly. Finally, Baz and the Dlg/Pins complex are required for the asymmetric localization of Numb. Thus, the Dlg/Pins complex responds to Fz signaling to establish planar asymmetry in the pI cell.
ISSN:0092-8674
1097-4172
DOI:10.1016/S0092-8674(01)00444-5