Reduced thiamine phosphate, but not thiamine diphosphate, in erythrocytes in elderly patients with congestive heart failure treated with furosemide

. Härdig L, Daae C, Dellborg M, Kontny F, Bøhmer T (Sahlgrenska University Hospital/Östra, Göteborg, Sweden, and Aker University Hospital, Oslo, Norway). Reduced thiamine phosphate, but not thiamine diphosphate, in erythrocytes in elderly patients with congestive heart failure treated with furosemid...

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Bibliographic Details
Published in:Journal of internal medicine 2000-05, Vol.247 (5), p.597-600
Main Authors: Härdig, L., Daae, C., Dellborg, M., Kontny, F., Bøhmer, T.
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Case-Control Studies
Chromatography, High Pressure Liquid
Cross-Sectional Studies
diuretics
Diuretics - therapeutic use
Drug toxicity and drugs side effects treatment
drug–nutrient interaction
Erythrocytes - metabolism
Female
Furosemide - therapeutic use
Heart Failure - blood
Heart Failure - drug therapy
Humans
Male
Medical sciences
Miscellaneous (drug allergy, mutagens, teratogens...)
nutrition
Pharmacology. Drug treatments
Statistics, Nonparametric
thiamine
Thiamine Monophosphate - blood
Thiamine Pyrophosphate - blood
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Summary:. Härdig L, Daae C, Dellborg M, Kontny F, Bøhmer T (Sahlgrenska University Hospital/Östra, Göteborg, Sweden, and Aker University Hospital, Oslo, Norway). Reduced thiamine phosphate, but not thiamine diphosphate, in erythrocytes in elderly patients with congestive heart failure treated with furosemide. J Intern Med 2000; 247: 597–600. Objectives. To measure the concentrations of thiamine and thiamine esters by high‐pressure liquid chromatography (HPLC) in elderly patients treated with furosemide for heart failure and in a control group. Design. A cross‐sectional study of blood thiamine and thiamine ester concentrations. Subjects. Forty‐one patients admitted to hospital for heart failure and 34 elderly living at home. No vitamin supplementation was allowed. Results. Compared with the healthy controls, furosemide‐treated patients had significantly reduced whole blood thiamine phosphate (TP; 4.4 ± 2.2 vs. 7.6 ± 2.0 nmol L–1) and thiamine diphosphate (TPP; 76 ± 21.5 vs. 91 ± 19.8 nmol L–1) (mean ± SD). When the thiamine concentrations were related to the haemoglobin concentrations, which were reduced in the heart failure patients, the levels of TP (nmol g–1 Hb) were 0.38 ± 0.26 vs. 0.54 ± 0.17 (P 
ISSN:0954-6820
1365-2796
DOI:10.1046/j.1365-2796.2000.00649.x