Targeting liver tumors with hyperthermia: Ferromagnetic embolization in a rabbit liver tumor model

Background and Objectives: Ferromagnetic embolization hyperthermia (FEH) consists of arterially embolizing liver tumors with ferromagnetic particles, and then applying an external alternating magnetic field to generate hysteretic heating within the embolized particles. The objective of this study wa...

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Bibliographic Details
Published in:Journal of surgical oncology 2001-09, Vol.78 (1), p.22-29
Main Authors: Moroz, Paul, Jones, Stephen K., Winter, Jillean, Gray, Bruce N.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Embolization, Therapeutic - methods
Ferric Compounds - therapeutic use
Gastroenterology. Liver. Pancreas. Abdomen
hepatic arterial infusion
Hepatic Artery
Hyperthermia, Induced
Infusions, Intra-Arterial
Iodized Oil - administration & dosage
lipiodol
liver cancer
Liver Neoplasms, Experimental - therapy
Liver. Biliary tract. Portal circulation. Exocrine pancreas
magnetic particles
Medical sciences
Rabbits
Tumors
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Summary:Background and Objectives: Ferromagnetic embolization hyperthermia (FEH) consists of arterially embolizing liver tumors with ferromagnetic particles, and then applying an external alternating magnetic field to generate hysteretic heating within the embolized particles. The objective of this study was to assess the ability of FEH to selectively target liver tumors with hyperthermia. Methods: Twenty rabbits containing hepatic VX2 carcinomas were arterially infused with ferromagnetic particles suspended in lipiodol, and then exposed to an external alternating magnetic field. Temperatures in the tumor, normal hepatic parenchyma (NHP), and rectum were recorded. Tumour and NHP were chemically analyzed for iron content, which was then correlated with the observed heating rates. Results: The mean tumor‐to‐NHP iron concentration ratio was 5.3:1 (P 
ISSN:0022-4790
1096-9098
DOI:10.1002/jso.1118