Human Immunodeficiency Virus Type 1 Envelope–Stimulated Interleukin-2 Production and Survival of Infected Children with Severe and Mild Clinical Disease

Interleukin (IL)–2 production after stimulation with human immunodeficiency virus type 1 (HIV-1) envelope (Env) peptides, tetanus toxoid, and phytohemagglutinin was measured in peripheral blood mononuclear cells (PBMC) from 25 HIV-1–infected children with mild and 24 with severe clinical disease and...

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Bibliographic Details
Published in:The Journal of infectious diseases 2001-09, Vol.184 (6), p.691-698
Main Authors: Kuhn, Louise, Meyers, Tammy M., Meddows-Taylor, Stephen, Simmank, Karen, Sherman, Gayle G., Tiemessen, Caroline T.
Format: Article
Language:English
Subjects:
AIDS
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Child
Child health services
Child, Preschool
Disease Progression
envelope protein
Female
Follow-Up Studies
Gene Products, env - immunology
HIV
HIV 1
HIV Infections - immunology
HIV Infections - mortality
HIV Infections - physiopathology
HIV-1 - immunology
Human immunodeficiency virus 1
Human viral diseases
Humans
Infant
Infant, Newborn
Infections
Infectious diseases
Interleukin-2 - biosynthesis
Lymphocyte Activation
Lymphocytes - drug effects
Lymphocytes - immunology
Lymphocytes - virology
Major Articles
Male
Medical sciences
Mortality
Pharmacology. Drug treatments
Phytohemagglutinins
Probability
Reference Values
RNA
RNA, Viral - blood
South Africa
Survival Rate
T lymphocytes
tetanus toxin
Tetanus Toxoid - immunology
Time Factors
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viral Load
Viruses
Citations: Items that cite this one
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Description
Summary:Interleukin (IL)–2 production after stimulation with human immunodeficiency virus type 1 (HIV-1) envelope (Env) peptides, tetanus toxoid, and phytohemagglutinin was measured in peripheral blood mononuclear cells (PBMC) from 25 HIV-1–infected children with mild and 24 with severe clinical disease and from 15 uninfected children. Env-specific IL-2 production was detected in PBMC of 26.5% of HIV-1–infected children but in none of the uninfected. The absence of Env-specific responses at enrollment among infected children was associated with a 6-fold increased risk of mortality within a year, adjusting for clinical severity (P=.04). Among those with severe clinical disease, Env-stimulated IL-2 reactivity in PBMC was negatively correlated with HIV-1 RNA copy numbers in plasma at enrollment and was positively correlated with CD4 T cell percentages 1 year later. HIV-specific cellular immune responses may play a role in containing progression of HIV-1 infection in children, despite early deficits in cell-mediated immunity
ISSN:0022-1899
1537-6613
DOI:10.1086/322988