TAJ, a Novel Member of the Tumor Necrosis Factor Receptor Family, Activates the c-Jun N-terminal Kinase Pathway and Mediates Caspase-independent Cell Death

We have isolated a novel member of the TNFR family, designated TAJ, that is highly expressed during embryonic development. TAJ possesses a unique cytoplasmic domain with no sequence homology to the previously characterized members of the TNFR family. TAJ interacts with the TRAF family members and ac...

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Bibliographic Details
Published in:The Journal of biological chemistry 2000-05, Vol.275 (20), p.15336-15342
Main Authors: Eby, Michael T., Jasmin, Alan, Kumar, Arvind, Sharma, Kiran, Chaudhary, Preet M.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Caspases - metabolism
Cell Death
Cell Line
Cloning, Molecular
Embryonic and Fetal Development
Female
Gene Expression Regulation, Developmental
Humans
JNK Mitogen-Activated Protein Kinases
Male
Mice
Mitogen-Activated Protein Kinases - metabolism
Molecular Sequence Data
Organ Specificity
Receptors, Tumor Necrosis Factor - chemistry
Receptors, Tumor Necrosis Factor - genetics
Receptors, Tumor Necrosis Factor - metabolism
Sequence Alignment
Sequence Homology, Amino Acid
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Summary:We have isolated a novel member of the TNFR family, designated TAJ, that is highly expressed during embryonic development. TAJ possesses a unique cytoplasmic domain with no sequence homology to the previously characterized members of the TNFR family. TAJ interacts with the TRAF family members and activates the JNK pathway when overexpressed in mammalian cells. Although it lacks a death domain, TAJ is capable of inducing apoptosis by a caspase-independent mechanism. Based on its unique expression profile and signaling properties, TAJ may play an essential role in embryonic development.
ISSN:0021-9258
1083-351X
DOI:10.1074/jbc.275.20.15336