Reference range of serum haptoglobin is haptoglobin phenotype-dependent in blacks

Reference values for serum haptoglobin (Hp), were established in a Black Zimbabwean population. The upper limit (2.15 g/l) is comparable to the one in Caucasians, but the lower limit (0.12 g/l) is much lower than the proposed interim international reference limit (0.3 g/l). Subjects that typed as Hp...

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Bibliographic Details
Published in:Clinica chimica acta 2000-06, Vol.296 (1), p.163-170
Main Authors: Kasvosve, Ishmael, Gomo, Zvenyika A.R., Gangaidzo, Innocent T., Mvundura, Elisha, Saungweme, Thokozile, Moyo, Victor M., Khumalo, Hlosukwazi, Boelaert, Johan R., Gordeuk, Victor R., Delanghe, Joris R.
Format: Article
Language:English
Subjects:
Adult
African Continental Ancestry Group
Aged
Aged, 80 and over
Alleles
Biological and medical sciences
Electrophoresis
Electrophoresis, Starch Gel
Female
Gene Frequency
Haptoglobin
Haptoglobins - analysis
Haptoglobins - genetics
Hematology
Hemoglobin
Humans
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Phenotype
Polymorphism
Polymorphism, Genetic
Reference Values
Sex Characteristics
Tropical medicine
Zimbabwe
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Summary:Reference values for serum haptoglobin (Hp), were established in a Black Zimbabwean population. The upper limit (2.15 g/l) is comparable to the one in Caucasians, but the lower limit (0.12 g/l) is much lower than the proposed interim international reference limit (0.3 g/l). Subjects that typed as Hp 0-0 by starch gel electrophoresis technique were retyped using high performance gel permeation chromatography. This resulted in a 32% decrease in the frequency of Hp 0-0, but an increase in Hp 2-2 and Hp 2-1M phenotype frequencies. In the Zimbabwean Blacks, the Hp 0-0 frequency was estimated to be 2.9%. Haptoglobin reference values were found to be Hp phenotype-dependent; highest values were found in Hp 1-1 (median 0.88 g/l; range 0.31–1.69 g/l) and in Hp 2-1 (median 0.90 g/l; range 0.31–2.22 g/l) and lower values (median 0.66 g/l; range 0.13–1.79 g/l) in Hp 2-2 subjects. The Hp 2-1M phenotype was characterized by low reference values (0.18–1.25 g/l) ( P
ISSN:0009-8981
1873-3492
DOI:10.1016/S0009-8981(00)00225-4