Fast sample preparation for analysis of tablets and capsules: the ball-mill extraction method

A new ball-mill extraction method for solid dosage forms was developed. It was used for tablets, and compared with a conventional (powdering and sonication) method applied in pharmaceutical analysis of solid dosage forms. The ball-mill sample preparation procedure is both quantitative and fast. No p...

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Bibliographic Details
Published in:Journal of pharmaceutical and biomedical analysis 2001-11, Vol.26 (4), p.599-604
Main Authors: Kok, S.J., Debets, A.J.J.
Format: Article
Language:English
Subjects:
Analysis
Automation
Biological and medical sciences
Capsules
Content uniformity
General pharmacology
Grinding
Medical sciences
Pharmaceutical analysis
Pharmaceutical Preparations - analysis
Pharmacology. Drug treatments
Powdering
Powders
Solid dosage forms
Tablets
Technology, Pharmaceutical
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Summary:A new ball-mill extraction method for solid dosage forms was developed. It was used for tablets, and compared with a conventional (powdering and sonication) method applied in pharmaceutical analysis of solid dosage forms. The ball-mill sample preparation procedure is both quantitative and fast. No powdering, weighing and sonication steps are needed in the sample preparation. The complete procedure takes 2 min (milling and extraction) and 5 min (centrifugation), respectively, much less than the conventional method in which sample preparation takes approximately 45–90 min. The samples are centrifuged in the mill vial, which saves time and avoids evaporation of solvent. Stainless steel extraction vials with different diameters were fabricated to enable the use of various extraction volumes. The extraction recovery was tested using various types of tablets (small, large and extended release tablets) with active compounds at low and higher concentrations, recoveries were comparable with the conventional method. The relative small investment and simplicity of the method makes it excellently suited for use in various pharmaceutical (development and quality assurance) laboratories.
ISSN:0731-7085
1873-264X
DOI:10.1016/S0731-7085(01)00488-5