Cerebrovascular Pathology in Alzheimer's Disease and Leukoaraiosis

: A high percentage of patients with Alzheimer's disease (AD) show evidence of white matter degeneration known as leukoaraiosis (LA), which is due to chronic ischemia. We found that the periventricular veins tend to become occluded by multiple layers of collagen in the vessel walls in the elder...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2000-04, Vol.903 (1), p.39-45
Main Authors: BROWN, WILLIAM R., MOODY, DIXON M., THORE, CLARA R., CHALLA, VENKATA R.
Format: Article
Language:English
Subjects:
Aged
Alzheimer Disease - pathology
Apoptosis
Brain - blood supply
Brain - pathology
Brain Ischemia - pathology
Cerebrovascular Circulation
Humans
Magnetic Resonance Imaging
Male
Neurodegenerative Diseases - pathology
Oligodendroglia - pathology
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Summary:: A high percentage of patients with Alzheimer's disease (AD) show evidence of white matter degeneration known as leukoaraiosis (LA), which is due to chronic ischemia. We found that the periventricular veins tend to become occluded by multiple layers of collagen in the vessel walls in the elderly. This collagen deposition is particularly excessive in LA lesions. Therefore, it is present in the brains of many AD patients, along with other ischemia‐causing cerebrovascular pathology. We found evidence that there is severe loss of oligodendrocytes in LA, due to extensive apoptosis. No evidence of inflammation was found in the LA lesions. In thick celloidin sections of AD brain, we have obtained detailed 3D views of small (early) deposits of amyloid (stained with β‐amyloid antibody) around capillaries (stained with collagen IV antibody).
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.2000.tb06348.x