Lack of evidence of osteo-medullary metastases at diagnosis in patients with high grade gliomas

High grade gliomas usually show a transient response to standard therapy by radiation. A local evolution leads to patient death in most of the cases. Necropsic series suggest that metastatic evolution is rather frequent in lungs, lymph nodes, bones or bone marrow. Are these metastatic deposits prese...

Full description

Saved in:
Bibliographic Details
Published in:Journal of neuro-oncology 2001-05, Vol.52 (3), p.249-252
Main Authors: FRAPPAZ, D, JOUVET, A, PIERRE, G. Saint, GIAMMARILE, F, GUYOTAT, J, DERUTY, R, JOUANNEAU, E, RANCHERE-VINCE, D
Format: Article
Language:English
Subjects:
Astrocytoma - diagnosis
Astrocytoma - diagnostic imaging
Astrocytoma - pathology
Astrocytoma - secondary
Biological and medical sciences
Biomarkers, Tumor - analysis
Bone Marrow - chemistry
Bone Marrow Examination
Bone Marrow Neoplasms - secondary
Bone Neoplasms - diagnostic imaging
Bone Neoplasms - secondary
Brain Neoplasms - diagnosis
Brain Neoplasms - pathology
Disease Progression
Ependymoma - diagnosis
Ependymoma - diagnostic imaging
Ependymoma - pathology
Ependymoma - secondary
Glial Fibrillary Acidic Protein - analysis
Glioblastoma - diagnosis
Glioblastoma - diagnostic imaging
Glioblastoma - pathology
Glioblastoma - secondary
Humans
Medical sciences
Neoplasm Metastasis
Neoplasm Proteins - analysis
Neurology
Prospective Studies
Radionuclide Imaging
Retrospective Studies
Tumors of the nervous system. Phacomatoses
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:High grade gliomas usually show a transient response to standard therapy by radiation. A local evolution leads to patient death in most of the cases. Necropsic series suggest that metastatic evolution is rather frequent in lungs, lymph nodes, bones or bone marrow. Are these metastatic deposits present initially? The authors retrospectively reviewed the bone marrow smears performed in 20 patients and the bone scans in 10 patients with high grade gliomas at time of diagnosis. None of these investigations showed metastatic deposits. It is thus suggested that metastatic deposits are probably a late event in the natural history of high grade gliomas. However, if local treatment could reach local control, metastases would probably become a major problem. Thus definitive cure of high grade glioma may require multidisciplinary approach.
ISSN:0167-594X
1573-7373
DOI:10.1023/A:1010616417169