Myocardial protection against ischaemia- reperfusion injury by a Polygonum multiflorum extract supplemented 'Dang-Gui decoction for enriching blood', a compound formulation, ex vivo

‘Dang‐Gui Decoction for Enriching the Blood’ (BE), a traditional Chinese formulation comprising Angelica sinensis and Astragalus membranaceus, is used for stimulating red blood cell production as well as enhancing cardiovascular function. In the present study, we have demonstrated the myocardial pro...

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Bibliographic Details
Published in:Phytotherapy research 2000-05, Vol.14 (3), p.195-199
Main Authors: Yim, T. K., Wu, W. K., Pak, W. F., Mak, D. H. F., Liang, S. M., Ko, K. M.
Format: Article
Language:English
Subjects:
Angelica sinensis
Animals
Astragalus membranaceus
Astragalus propinquus
China
Drugs, Chinese Herbal - pharmacology
ex vivo
Female
glutathione
Glutathione - metabolism
Glutathione Peroxidase - metabolism
Glutathione Reductase - metabolism
Heart - drug effects
In Vitro Techniques
myocardial ischaemia-reperfusion
Myocardial Reperfusion Injury - prevention & control
Myocardium - metabolism
Plant Extracts - pharmacology
Plant Roots
Plants, Medicinal
Polygonum multiflorum
Rats
Rats, Sprague-Dawley
Species Specificity
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Summary:‘Dang‐Gui Decoction for Enriching the Blood’ (BE), a traditional Chinese formulation comprising Angelica sinensis and Astragalus membranaceus, is used for stimulating red blood cell production as well as enhancing cardiovascular function. In the present study, we have demonstrated the myocardial protection afforded by BE pretreatment against ischaemia‐reperfusion (IR) injury in isolated‐perfused rat hearts. A more complete and potent myocardial protection against IR injury was also shown by a Polygonum multiflorum extract supplemented BE preparation (BEA). The results suggest that the more potent cardioprotective action of BEA may be related to its ability to sustain the myocardial glutathione antioxidant status under conditions of IR‐induced oxidative stress, which may possibly in turn result from the synergistic interaction between the BE and Polygonum extract. Copyright © 2000 John Wiley & Sons, Ltd.
ISSN:0951-418X
1099-1573
DOI:10.1002/(SICI)1099-1573(200005)14:3<195::AID-PTR629>3.0.CO;2-4