Microparticles for intranasal immunization

Of the several routes available for mucosal immunization, the nasal route is particularly attractive because of ease of administration and the induction of potent immune responses, particularly in the respiratory and genitourinary tracts. However, adjuvants and delivery systems are required to enhan...

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Bibliographic Details
Published in:Advanced drug delivery reviews 2001-09, Vol.51 (1), p.127-141
Main Authors: Vajdy, Michael, O’Hagan, Derek T.
Format: Article
Language:English
Subjects:
Adjuvants
Administration, Intranasal
Animals
Bacterial Toxins - immunology
DNA vaccines
Drug Delivery Systems
Enterotoxins - immunology
Escherichia coli Proteins
Humans
Immunization
Microparticles
Mucosal delivery
Nasal immunization
Polyglactin 910 - administration & dosage
T-Lymphocytes, Cytotoxic - immunology
Vaccines - administration & dosage
Vaccines, DNA - administration & dosage
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Summary:Of the several routes available for mucosal immunization, the nasal route is particularly attractive because of ease of administration and the induction of potent immune responses, particularly in the respiratory and genitourinary tracts. However, adjuvants and delivery systems are required to enhance immune responses following nasal immunization. This review focuses on the use of microparticles as adjuvants and delivery systems for protein and DNA vaccines for nasal immunization. In particular we discuss our own work on poly(lactide co-glycolide) (PLG) microparticles with entrapped protein or adsorbed DNA as a vaccine delivery system. The possible mechanisms involved in the enhancement of immune responses through the use of DNA adsorbed onto PLG microparticles are also discussed.
ISSN:0169-409X
1872-8294
DOI:10.1016/S0169-409X(01)00167-3